4-羟基-3-(3-甲基-3-丁烯-1-炔基)苯甲醛 | 121007-17-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-羟基-3-(3-甲基-3-丁烯-1-炔基)苯甲醛
• 英文名称: 4-hydroxy-3-(3-methylbut-3-en-1-yn-1-yl)benzaldehyde
• 英文别名: 4-hydroxy-3-(3-methylbut-3-en-1-ynyl)benzaldehyde；Eutypine
• CAS: 121007-17-8
• 化学式: C₁₂H₁₀O₂
• 分子量: 186.21
• InChiKey: SFCYVTIQMNZUCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-羟基-3-(3-甲基-3-丁烯-1-炔基)苯甲醛 在 sodium chlorite 、 氨基磺酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 1.0h， 以79%的产率得到eutypinic acid
  参考文献：
  名称：

  从Eutypa lata（Pers; F.）TUL合成天然乙炔化合物

  摘要：

  一系列新炔属化合物的合成1 - 7，最近从真菌中分离Eutypa LATA，进行说明。关键步骤是受保护的芳基卤化物与炔属链之间的偶联反应，即乙炔化亚铜（流程1）。还成功地使用了双（三苯基膦）二氯化钯（[Pd（PPh 3）2 Cl 2 ]）作为催化剂，效率更高。

  DOI：

  10.1002/hlca.19930760126
• 作为产物：
  描述：

  4-羟基-3-碘苯甲醛 在 ammonium hydroxide 、 sodium hydroxide 、 copper(l) iodide 、 盐酸羟胺 、 三乙胺 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 5.75h， 生成 4-羟基-3-(3-甲基-3-丁烯-1-炔基)苯甲醛
  参考文献：
  名称：

  从Eutypa lata（Pers; F.）TUL合成天然乙炔化合物

  摘要：

  一系列新炔属化合物的合成1 - 7，最近从真菌中分离Eutypa LATA，进行说明。关键步骤是受保护的芳基卤化物与炔属链之间的偶联反应，即乙炔化亚铜（流程1）。还成功地使用了双（三苯基膦）二氯化钯（[Pd（PPh 3）2 Cl 2 ]）作为催化剂，效率更高。

  DOI：

  10.1002/hlca.19930760126

文献信息

• POLYNUCLEOTIDES, PRIMERS, AND METHODS FOR DETECTION OF TRANSGENIC EVENT, GENETIC CONSTRUCT, KIT FOR DETECTION MATERIAL FROM A PLANT SAMPLE, EVENT CTC75064-3, INSECT-RESISTANT SUGARCANE PLANT, AND METHOD FOR PRODUCING AN INSECT-RESISTANT SUGARCANE PLANT, PLANT CELL, PLANT PART OR SEED
  申请人：Centro de Tecnologia Canavieira S.A

  公开号：EP3995583A1

  公开（公告）日：2022-05-11

  The present invention relates to the field of biotechnology. More precisely, a genetic construct and method for producing a transgenic plant event, especially a sugarcane event (Saccharum spp.), which is resistant to infestation by the Diatraea saccharalis pest, popularly known as ordinary borer, reed borer or just borer. The invention describes the event, the methods for event identification as well as the insertion detection method based on the unique region of intersection between the insert and the host genome and the flanking regions that characterize it.

  本发明涉及生物技术领域。更确切地说，是一种基因构建体和方法，用于产生一种转基因植物事件，特别是甘蔗事件（Saccharum spp.），该事件可抵抗 Diatraea saccharalis 害虫（俗称普通钻心虫、芦苇钻心虫或刚钻心虫）的侵染。本发明描述了该事件、事件识别方法以及基于插入物与宿主基因组之间的独特交叉区域和侧翼区域特征的插入物检测方法。
• POLYNUCLEOTIDES, PRIMERS, AND METHODS FOR DETECTION OF TRANSGENIC EVENT, GENETIC CONSTRUCT, KIT FOR DETECTION MATERIAL FROM A PLANT SAMPLE, EVENT CTC79005-2, INSECT-RESISTANT SUGARCANE PLANT, AND METHOD FOR PRODUCING AN INSECT-RESISTANT SUGARCANE PLANT, PLANT CELL, PLANT PART OR SEED
  申请人：Centro de Tecnologia Canavieira S.A

  公开号：EP4001418A1

  公开（公告）日：2022-05-25

  The present invention relates to the field of biotechnology. More precisely, a genetic construct and method for producing a transgenic plant event, especially a sugarcane event (Saccharum spp.), which is resistant to infestation by the Diatraea saccharalis pest, popularly known as a pest, is described ordinary borer, reed borer or just borer. The invention describes the event, the methods for event identification as well as the insertion detection method based on the unique region of intersection between the insert and the host genome and the flanking regions that characterize it.

  本发明涉及生物技术领域。更确切地说，本发明描述了一种用于产生转基因植物事件，特别是甘蔗事件（Saccharum spp.）的基因构建体和方法，该转基因植物事件能够抵抗 Diatraea saccharalis 害虫（俗称害虫），即普通螟虫、芦苇螟虫或仅仅是螟虫的侵扰。本发明描述了该事件、事件识别方法以及基于插入物与宿主基因组之间的独特交叉区域及其侧翼区域特征的插入物检测方法。
• Insecticidal proteins and synergistic combinations thereof
  申请人：——

  公开号：US20040250313A1

  公开（公告）日：2004-12-09

  The present invention relates to insecticidal proteins. In a particular embodiment the invention provides an insecticidal protein having the amino acid sequence depicted as SEQ ID No. 1. The invention also provides an insecticidal synergistic protein combination comprising a first insecticidal protein according to the invention in combination with a further protein. Preferably the further protein is an insecticidal crystal endotoxin (CRY) protein Also provided are polynucleotides encoding the proteins and plants which are capable of producing the proteins or protein combination. The proteins according to the invention are particularly suitable for the production of plants which are resistant and/or tolerant to insects.

  本发明涉及杀虫蛋白。在一个特定的实施方案中，本发明提供了一种具有 SEQ ID 编号 1 所示氨基酸序列的杀虫蛋白。本发明还提供了一种杀虫增效蛋白组合物，包括根据本发明的第一种杀虫蛋白与另一种蛋白的组合。此外，本发明还提供了编码这些蛋白质的多核苷酸以及能够生产这些蛋白质或蛋白质组合的植物。本发明的蛋白质特别适用于生产抗虫和/或耐虫植物。
• Cot102 insecticidal cotton
  申请人：Ellis Murray Daniel

  公开号：US20060130175A1

  公开（公告）日：2006-06-15

  The present application relates an insect resistant transgenic cotton plant. In particular, it relates to a specific event, designated COT102. The application also relates to polynucleotides which are characteristic of the COT102 event, plants comprising said polynucleotides, and methods of detecting the COT102 event. The COT102 event exhibits a novel genotype comprising two expression cassettes. The first cassette comprises a suitable promoter for expression in plants operably linked to a gene that encodes a VIP3A insecticidal toxin, useful in controlling a wide spectrum of lepidopteran insect pests, and a suitable polyadenylation signal. The second cassette comprises a gene which, when expressed, can be used as a selectable marker.

  本申请涉及一种抗虫转基因棉花植物。特别是，它涉及一种特定的事件，命名为 COT102。本申请还涉及具有 COT102 事件特征的多核苷酸、包含所述多核苷酸的植物以及检测 COT102 事件的方法。COT102 事件表现出一种包含两个表达盒的新型基因型。第一个表达盒包括一个适合在植物中表达的启动子，该启动子与一个编码 VIP3A 杀虫毒素的基因和一个适合的多聚腺苷酸化信号可操作地连接，VIP3A 杀虫毒素可用于控制多种鳞翅目害虫。第二个盒包括一个基因，该基因在表达时可用作可选择标记。
• Synthesis and Structure−Phytotoxicity Relationships of Acetylenic Phenols and Chromene Metabolites, and Their Analogues, from the Grapevine Pathogen <i>Eutypa </i><i>l</i><i>ata</i>
  作者：Leverett R. Smith、Noreen Mahoney、Russell J. Molyneux

  DOI：10.1021/np020415t

  日期：2003.2.1

  Eutypa lata, the fungus responsible for dying-arm disease in grapevines, produces a number of structurally related secondary metabolites, of which eutypine (1) has been implicated as the principal phytotoxin. However, analysis of an E. lata strain from California known to be pathogenic to grapevines showed that eutypine was not present, suggesting that other metabolites could be phytotoxic. Investigation of the relative phytotoxicities of individual metabolites has been limited by insufficient material and lack of a reliable bioassay. Metabolites of particular interest and their precursors were therefore synthesized, and a rapid, quantitative bioassay via topical application of individual compounds to disks of grape leaves and measurement of chlorophyll loss was developed to provide a relative measure of tissue damage. The recently reported metabolite eulatachromene (2) was found to have phytotoxicity greater than that of eutypine (1). The cyclization product, 5-formyl-2-methylvinyl[1]benzofuran (3), also showed significant activity, whereas the reduction product, eutypinol (4), was inactive, as was the quinol, siccayne (5). These results indicate that before strains of Eutypa are incriminated as pathogenic they must be analyzed for the presence or absence of specific constituents for which the phytotoxicity has been unequivocally established.