| 1065491-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1065491-29-3
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: AOKCITYRUHCIPK-NDRDAGNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  17.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  、 lead(IV) tetraacetate 以 苯 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Microwave-assisted domino reactions: function-compatibility, modulation, and greening efforts

  摘要：

  Herein we report a microwave-assisted version of a domino protocol, providing ready access to a wide variety of complex oxygen heterocycles. The latter can be converted to stereochemically, well-defined, variously substituted carbocycles, since reaction conditions and the substitution pattern can be tailored to fit a particular type of transformation. Microwave assistance, the influence of solvent, temperature, the function compatibility, and the use of PhI(OAc)(2) as a domino promoter are investigated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.06.026
• 作为产物：
  描述：

  (R,E)-7a-(prop-1-en-1-yl)-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione 、 乙二醇 在 4 A molecular sieve 、 对甲苯磺酸 作用下， 反应 0.75h， 生成
  参考文献：
  名称：

  Microwave-assisted domino reactions: function-compatibility, modulation, and greening efforts

  摘要：

  Herein we report a microwave-assisted version of a domino protocol, providing ready access to a wide variety of complex oxygen heterocycles. The latter can be converted to stereochemically, well-defined, variously substituted carbocycles, since reaction conditions and the substitution pattern can be tailored to fit a particular type of transformation. Microwave assistance, the influence of solvent, temperature, the function compatibility, and the use of PhI(OAc)(2) as a domino promoter are investigated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.06.026