N-{4-[(5-Chloropyridin-3-yl)oxy]-3-propionylphenyl}-N'-(3-methoxyphenyl)urea | 508212-46-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-{4-[(5-Chloropyridin-3-yl)oxy]-3-propionylphenyl}-N'-(3-methoxyphenyl)urea
• 英文别名: 1-[4-(5-chloropyridin-3-yl)oxy-3-propanoylphenyl]-3-(3-methoxyphenyl)urea
• CAS: 508212-46-2
• 化学式: C₂₂H₂₀ClN₃O₄
• 分子量: 425.871
• InChiKey: TTYPXOWMVDCJFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-{5-amino-2-[(5-chloropyridin-3-yl)oxy]phenyl}propan-1-one 、 3-甲氧基苯异氰酸 以 四氢呋喃 为溶剂， 反应 5.0h， 以52.1%的产率得到N-{4-[(5-Chloropyridin-3-yl)oxy]-3-propionylphenyl}-N'-(3-methoxyphenyl)urea
  参考文献：
  名称：

  EP1437344

  摘要：

  公开号：

文献信息

• Benzine derivatives, process for preparing the same and use thereof
  申请人：——

  公开号：US20040259912A1

  公开（公告）日：2004-12-23

  Novel benzene derivatives represented by the formula (I): 1 wherein R 1 , R 4 and R 6 each independently represents a hydrogen atom, a halogen atom or a hydrocarbon group, R 2 represents a hydrocarbon group or a heterocyclic group, R 3 represents a hydrocarbon group, NR 7′ R 7 or OR 8 (wherein R 7′ represents a hydrogen atom or a hydrocarbon group, R 7 represents a non-aromatic group, or R 7′ and R 7 may form a ring with the adjacent nitrogen atom, and R 8 represents a hydrocarbon group or a heterocyclic group), R 5 represents a hydrocarbon group or a heterocyclic group (except for a quinolyl group), R 5′ represents a hydrogen atom, or a hydrocarbon group, or R 5 and R 5′ may form a ring with the adjacent nitrogen atom, and R 5″ represents a hydrogen atom or a hydrocarbon group, which have vanilloid receptor agonist activity and are useful as a drug such as an analgesic and an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

  式(I)所表示的新型苯衍生物，其中R1、R4和R6各自独立地表示氢原子、卤素原子或烃基，R2表示烃基或杂环基，R3表示烃基、NR7′R7或OR8（其中R7′表示氢原子或烃基，R7表示非芳香族基团，或R7′和R7可与相邻的氮原子形成环，R8表示烃基或杂环基），R5表示烃基或杂环基（除了喹啉基团），R5′表示氢原子或烃基，或R5和R5′可与相邻的氮原子形成环，R5″表示氢原子或烃基，具有vanilloid受体激动剂活性，并且可用作药物，例如镇痛剂和预防和/或治疗尿频和/或尿失禁的药剂。
• BENZENE DERIVATIVES,PROCESS FOR PREPARING THE SAME AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1437344A1

  公开（公告）日：2004-07-14

  Novel benzene derivatives represented by the formula (I) : wherein R1, R4 and R6 each independently represents a hydrogen atom, a halogen atom or a hydrocarbon group, R2 represents a hydrocarbon group or a heterocyclic group, R3 represents a hydrocarbon group, NR7'R7 or OR8 (wherein R7' represents a hydrogen atom or a hydrocarbon group, R7 represents a non-aromatic group, or R7' and R7 may form a ring with the adjacent nitrogen atom, and R8 represents a hydrocarbon group or a heterocyclic group), R5 represents a hydrocarbon group or a heterocyclic group (except for a quinolyl group), R5' represents a hydrogen atom, or a hydrocarbon group, or R5 and R5' may form a ring with the adjacent nitrogen atom, and R5" represents a hydrogen atom or a hydrocarbon group, which have vanilloid receptor agonist activity and are useful as a drug such as an analgesic and an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

  由式(I)代表的新型苯衍生物： 其中 R1、R4 和 R6 各自独立地代表氢原子、卤素原子或烃基，R2 代表烃基或杂环基，R3 代表烃基、NR7'R7 或 OR8（其中 R7'代表氢原子或烃基，R7 代表非芳香族基团，或 R7'和 R7 可与相邻的氮原子形成环，R8 代表烃基或杂环基）、R5代表烃基或杂环基（喹啉基除外），R5'代表氢原子或烃基，或 R5和R5'可与相邻的氮原子形成环，R5 "代表氢原子或烃基，它们具有香兰素受体激动剂活性，可用作药物，如镇痛剂和预防和/或治疗尿频和/或尿失禁的药物。
• EP1437344
  申请人：——

  公开号：——

  公开（公告）日：——