[Pt(Norfloxacin-H)2] | 1354953-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [Pt(Norfloxacin-H)2]
• 英文别名: [Pt(NFL)2]；1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylate;platinum(2+)
• CAS: 1354953-54-0
• 化学式: C₃₂H₃₄F₂N₆O₆Pt
• 分子量: 831.735
• InChiKey: PCPNZZQHOMNMAQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.14
• 重原子数：
  47
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 norfloxacin sodium salt 以 水 为溶剂， 以73%的产率得到[Pt(Norfloxacin-H)2]
  参考文献：
  名称：

  DNA interaction and in-vitro antibacterial studies of fluoroquinolone based platinum(II) complexes

  摘要：

  A series of square planar complexes of the type [Pt(FQ)(2)] (where FQ is deprotonated fluoroquinolone family drug) has been synthesized and characterized. The synthesized complexes have been checked for their in-vitro antimicrobial activity against two Gram((+ve)) and three Gram((-ve)) bacterial species. Intrinsic binding constant (K-b) and mode of binding of complexes toward Herring Sperm DNA (HS DNA) have been determined using absorption titration and viscosity measurement, suggesting the partial intercalative mode of binding. Cleavage ability of complexes has been checked using gel electrophoresis technique and the result shows that the synthesized complexes cleave the DNA more efficiently compared to their respective fluoroquinolones and metal salt. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2011.10.037

文献信息

• DNA interaction and in-vitro antibacterial studies of fluoroquinolone based platinum(II) complexes
  作者：Mohan N. Patel、Deepen S. Gandhi、Pradhuman A. Parmar

  DOI：10.1016/j.inoche.2011.10.037

  日期：2012.1

  A series of square planar complexes of the type [Pt(FQ)(2)] (where FQ is deprotonated fluoroquinolone family drug) has been synthesized and characterized. The synthesized complexes have been checked for their in-vitro antimicrobial activity against two Gram((+ve)) and three Gram((-ve)) bacterial species. Intrinsic binding constant (K-b) and mode of binding of complexes toward Herring Sperm DNA (HS DNA) have been determined using absorption titration and viscosity measurement, suggesting the partial intercalative mode of binding. Cleavage ability of complexes has been checked using gel electrophoresis technique and the result shows that the synthesized complexes cleave the DNA more efficiently compared to their respective fluoroquinolones and metal salt. (C) 2011 Elsevier B.V. All rights reserved.