6-(3-chloro-2-fluorophenylamino)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride | 1048998-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(3-chloro-2-fluorophenylamino)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• CAS: 1048998-57-7
• 化学式: C₁₈H₁₄ClFN₂O₃*ClH
• 分子量: 397.233
• InChiKey: BBUYJILUMXWZJU-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 、 水 、 盐酸 作用下， 以 水 为溶剂， 生成 6-(3-chloro-2-fluorophenylamino)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
  参考文献：
  名称：

  Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors

  摘要：

  A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.

  DOI：

  10.1021/jm8003784