(4R,13R)-7,10-diisopropyl-4,13-dimethyl-1-oxa-8,9-diazacyclopentadeca-7,9-dien-2-one | 1201648-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (4R,13R)-7,10-diisopropyl-4,13-dimethyl-1-oxa-8,9-diazacyclopentadeca-7,9-dien-2-one
• CAS: 1201648-53-4
• 化学式: C₂₀H₃₆N₂O₂
• 分子量: 336.518
• InChiKey: XMTQCRHBCBJFTR-IAGOWNOFSA-N

物化性质

• 沸点：
  460.5±34.0 °C(predicted)
• 密度：
  1.00±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  (R)-3,7-dimethyl-6-oxooctanoic acid (R)-3,7-dimethyl-6-oxooctyl ester 在 一水合肼 作用下， 以 1,4-二氧六环 为溶剂， 以40%的产率得到(4R,13R)-7,10-diisopropyl-4,13-dimethyl-1-oxa-8,9-diazacyclopentadeca-7,9-dien-2-one
  参考文献：
  名称：

  Synthesis from L-menthol of optically active macrolides with N-containing (azine or hydrazide) groups

  摘要：

  含有吖嗪或酰肼基团的潜在有用的15元和20元大环内酯是由L-薄荷醇通过3R,7-二甲基-6-氧代辛基-3R,7-二甲基-6-在室温下的[1+1]-缩合合成的。辛酸氧酯，由3R,7-二甲基-6-氧代辛醛与水合肼或丙二酸二酰肼通过Tishchenko反应得到。

  DOI：

  10.1007/s10600-009-9407-x

文献信息

• Synthesis of macrolides containing an azine or hydrazide fragment via successive tishchenko disproportionation and [1 + 1]-condensation
  作者：G. Yu. Ishmuratov、G. R. Mingaleeva、M. P. Yakovleva、R. R. Muslukhov、O. O. Shakhanova、E. M. Vyrypaev、A. G. Tolstikov

  DOI：10.1134/s1070428011090259

  日期：2011.9

  Eight potentially useful 15-, 17-, 20-, and 22-25-membered macrolides having an azine or hydrazide fragment were synthesized starting from L-menthol, tetrahydropyran, and 4-methyltetrahydropyran via [1 + 1]-condensation of hydrazine hydrate and some dicarboxylic dihydrazides with 7-oxooctyl 7-oxooctanoate, 3-methyl-7-oxooctyl 3-methyl-7-oxooctanoate, and (3R)-3,7-dimethyl-6-oxooctyl (3R)-3,7-dimethyl-6-oxooctanoate obtained by the Tishchenko reaction from 7-oxo-, 3-methyl-7-oxo, and (3R)-3,7-dimethyl-6-oxooctanals, respectively.