1-hydroxy-4-methyl-cyclohexanecarbonitrile | 933-45-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-hydroxy-4-methyl-cyclohexanecarbonitrile
• 英文别名: 4-Methyl-cyclohexanon-cyanhydrin；4-Methyl-1-hydroxycyclohexanecarbonitrile；1-hydroxy-4-methylcyclohexane-1-carbonitrile
• CAS: 933-45-9
• 化学式: C₈H₁₃NO
• 分子量: 139.197
• InChiKey: ZZNWDVTYICRGJF-UHFFFAOYSA-N

物化性质

• 沸点：
  128 °C(Press: 20 Torr)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-hydroxy-4-methyl-cyclohexanecarbonitrile 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 氯化亚砜 作用下， 以 吡啶 为溶剂， 反应 0.83h， 生成 4-Methyl-1-[1-methyl-2-nitro-3-(tetrahydro-pyran-2-yloxy)-propyl]-cyclohex-2-enecarbonitrile
  参考文献：
  名称：

  Synthetic studies toward verrucarol. 1. Synthesis of the AB ring system

  摘要：

  DOI：

  10.1021/jo01312a003
• 作为产物：
  描述：

  4-甲基环己酮 在 sodium hydrogensulfite 作用下， 生成 1-hydroxy-4-methyl-cyclohexanecarbonitrile
  参考文献：
  名称：

  Qudrat-i-Khuda; Ghosh, Journal of the Indian Chemical Society, 1940, vol. 17, p. 19,24

  摘要：

  DOI：

文献信息

• [EN] CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS<br/>[FR] CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES EN TANT QU'INHIBITEURS DE JANUS KINASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013040863A1

  公开（公告）日：2013-03-28

  Cycloalkylnitrile pyrazole carboxamides as JAK inhibitors useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer are provided.

  提供环烷基腈吡唑羧酰胺作为JAK抑制剂，用于治疗JAK介导的疾病，如类风湿关节炎、哮喘、慢性阻塞性肺病和癌症。
• STRUCTURE AND PROPERTIES OF CYCLIC COMPOUNDS: XI. DISSOCIATION CONSTANTS OF THE CYANOHYDRINS OF SOME METHYLCYCLOHEXANONES
  作者：Owen H. Wheeler、Jacob Z. Zabicky

  DOI：10.1139/v58-091

  日期：1958.4.1

  The dissociation constants of the cyanohydrins of a series of methylcyclohexanones have been measured. The polymethylcyclohexanone cyanohydrins show increasing instability on substitution owing to the effects of "axial crowding". The cyanohydrins of 3- and 4-methylcyclohexanone were found to be more stable than that of cyclohexanone and to explain this a new concept of "equatorial interference" is

  已经测量了一系列甲基环己酮的氰醇的解离常数。由于“轴向拥挤”的影响，聚甲基环己酮氰醇在取代时表现出越来越大的不稳定性。发现 3- 和 4- 甲基环己酮的氰醇比环己酮的氰醇更稳定，为了解释这一点，引入了“赤道干扰”的新概念。
• Preparation and characterization of some α,α-disubstituted-α-hydroxythiolesters
  作者：Wilma E. Elias

  DOI：10.1139/v70-614

  日期：1970.12.1

  A series of α,α-disubstituted-α-hydroxythiolesters has been prepared from ketone cyanohydrins by the Pinner reaction. The esters have been characterized both by classical methods and by analysis of...

  以酮氰醇为原料，通过Pinner反应制备了一系列α,α-二取代-α-羟基硫酯。酯已通过经典方法和分析...
• Union density effects in the supermarket industry
  作者：Robert C. Johansson、Jay S. Coggins

  DOI：10.1007/s12122-002-1035-1

  日期：2002.12

  Unions provide higher than competitive wages for members, but their effect on non-union wages is not clear. We investigate the effect of union density on supermarket wages from 1986 to 1993, a period of declining real wages and declining union membership. Full-information maximum likelihood techniques are used to estimate log wage equations for both the union and nonunion sectors. Decomposition techniques then separate the union wage premium into the relative effects of densities and union membership. We find a significant, positive effect of union density for both union and nonunion employees. This effect explains approximately one-third of the union-nonunion wage differential.

  工会为会员提供的工资高于竞争性工资，但它们对非工会工资的影响尚不清楚。我们调查了1986年至1993年期间工会密度对超市工资的影响，这一时期实际工资和工会会员数量都在下降。我们使用全信息最大似然技术来估计工会和非工会部门的工资对数方程。然后，分解技术将工会工资溢价分解为密度和工会会员的相对影响。我们发现工会密度对工会和非工会员工都有显著的积极影响。这种影响解释了工会和非工会工资差异的约三分之一。
• Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
  申请人：Brubaker Jason

  公开号：US08962608B2

  公开（公告）日：2015-02-24

  The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

  本发明提供了I式化合物，它们是JAK抑制剂，因此可用于治疗由JAK介导的疾病，如类风湿性关节炎、哮喘、COPD和癌症。