2-(4-氟苯基)-4-(碘甲基)恶唑 | 501361-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(4-氟苯基)-4-(碘甲基)恶唑
• 英文名称: 2-(4-fluorophenyl)-4-(iodomethyl)oxazole
• 英文别名: 2-(4-fluorophenyl)oxazol-4-ylmethyl iodide；2-(4-fluorophenyl)-4-iodomethyloxazole；4-iodomethyl-2-(4-fluorophenyl)oxazole；2-(4-fluorophenyl)-4-(iodomethyl)-1,3-oxazole
• CAS: 501361-99-5
• 化学式: C₁₀H₇FINO
• 分子量: 303.075
• InChiKey: LMXNHQBPCRGUJX-UHFFFAOYSA-N

物化性质

• 沸点：
  349.7±52.0 °C(Predicted)
• 密度：
  1.781±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-氟苯基)-4-(碘甲基)恶唑 在 sodium amide 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 9.5h， 生成 4-(2-(4-fluorophenyl)oxazol-4-yl)-1-methylpiperidine-4-carbonitrile
  参考文献：
  名称：

  COMPOUNDS AND METHODS for the inhibition of HDAC

  摘要：

  公开号：

  EP2533783B1
• 作为产物：
  描述：

  4-(氯甲基)-2-(4-氟苯基)-1,3-唑 在 sodium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 2-(4-氟苯基)-4-(碘甲基)恶唑
  参考文献：
  名称：

  Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives

  摘要：

  描述了一种用于制备手性、非对映体、顺式配置的1,3-二取代环己醇衍生物的过程，其化学式为(I)，其中基团如所定义，通过酶促光学分辨的方法。

  公开号：

  US20040209931A1

文献信息

• [EN] COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS ET PROCÉDÉS
  申请人：TEMPERO PHARMACEUTICALS INC

  公开号：WO2011088187A1

  公开（公告）日：2011-07-21

  Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, n and L are as defined herein, and methods of making and using the same.

  揭示了具有以下公式的化合物：其中X1、X2、X3、R1、R2、R3、R4、Y、A、n和L的定义如本文所述，并且揭示了制备和使用这些化合物的方法。
• Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：Glombik Heiner

  公开号：US06884812B2

  公开（公告）日：2005-04-26

  Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.

  本发明涉及二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。所述化合物包括具有以下式I的那些基团，其中所述基团如定义，以及其生理上可接受的盐和其制备方法。这些化合物通常具有降脂和/或三酸甘油酯降低作用，并且适用于治疗脂质代谢紊乱、II型糖尿病和X综合征等疾病。
• Diarylcycloalkyl derivatives, processes for their preparation and their use s pharmaceuticals
  申请人：——

  公开号：US20030144332A1

  公开（公告）日：2003-07-31

  Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.

  披萨店的员工们正在忙着准备今晚的外卖订单。
• 6-OXAZOL-4-YLMETHOLMETHOXY-ALKO-ALKOXYMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVES FORMING PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) LIGANDS, PROCESS FOR THEIR PREPARATION AND METHODS OF USE THEREOF
  申请人：STAPPER Christian

  公开号：US20080171776A1

  公开（公告）日：2008-07-17

  The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptor (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein R1-R6 are further defined herein.

  本发明涵盖了用于治疗代谢性疾病的化合物和组合物，尤其是血液中与胰岛素相关的代谢性疾病，如高脂血症、糖尿病、胰岛素抵抗等，其中包括带有环己基甲氧基取代基和其盐的乙酸衍生物。作为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂，本发明涉及式I的化合物，其中R1-R6在此进一步定义。
• COMPOUNDS AND METHODS
  申请人：Baloglu Erkan

  公开号：US20120322827A1

  公开（公告）日：2012-12-20

  Disclosed are compounds having the formula: wherein X 1 , X 2 , X 3 , R 1 , R 2 , R 3 , R 4 , Y, A, n and L are as defined herein, and methods of making and using the same.

  本发明揭示了具有以下公式的化合物：其中X1、X2、X3、R1、R2、R3、R4、Y、A、n和L的定义如本文所述，并且揭示了制备和使用这些化合物的方法。