Methyl 2-(5-but-3-enyl-4-phenylimidazol-1-yl)hex-4-ynoate | 874097-07-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(5-but-3-enyl-4-phenylimidazol-1-yl)hex-4-ynoate
• 英文别名: methyl 2-(5-but-3-enyl-4-phenylimidazol-1-yl)hex-4-ynoate
• CAS: 874097-07-1
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: GXMDEDYZXFBJKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 2-(5-but-3-enyl-4-phenylimidazol-1-yl)hex-4-ynoate 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 以63%的产率得到methyl (7E)-1-phenyl-7-prop-1-en-2-yl-5,6,9,10-tetrahydroimidazo[1,5-a]azocine-5-carboxylate
  参考文献：
  名称：

  Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions

  摘要：

  A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materials in an expedient fashion with good overall yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.089
• 作为产物：
  描述：

  辛-1,7-二烯-4,5-二醇 在 sodium periodate 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 Methyl 2-(5-but-3-enyl-4-phenylimidazol-1-yl)hex-4-ynoate
  参考文献：
  名称：

  Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions

  摘要：

  A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materials in an expedient fashion with good overall yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.089

文献信息

• Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions
  作者：Vijaya Gracias、Alan F. Gasiecki、Stevan W. Djuric

  DOI：10.1016/j.tetlet.2005.10.089

  日期：2005.12

  A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materials in an expedient fashion with good overall yields. (c) 2005 Elsevier Ltd. All rights reserved.