7-oxo-2,3-dihydro-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | 56346-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-oxo-2,3-dihydro-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• 英文别名: 7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid；10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid
• CAS: 56346-15-7
• 化学式: C₁₂H₉NO₄
• mdl: MFCD16991212
• 分子量: 231.208
• InChiKey: YILGXIZRZUDENO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Tricyclic amine derivatives
  申请人：——

  公开号：US20010037030A1

  公开（公告）日：2001-11-01

  The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. 1 wherein Q preferably represents the following partial structure which may have various substituents: 2

  本发明涉及一种具有三环胺取代基的化合物，该化合物可以具有各种取代基，表示为式(I)的盐或水合物，盐的水合物和包含它们作为活性成分的药物。它们对革兰氏阴性菌和革兰氏阳性菌表现出优异的抗菌活性，具有令人满意的效果和安全性，适用于治疗传染病。其中Q最好表示以下可能具有各种取代基的部分结构：2
• Aminomethylpyrrolidine derivatives having aromatic substituents
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20040209940A1

  公开（公告）日：2004-10-21

  This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R 1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both. 1 In the formula, R 2 , R 3 : hydrogen atom, an alkyl group; R 4 , R 5 , R 6 : hydrogen atom, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R 7 , R 8 : hydrogen atom, an alkyl group; R 9 : an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R 10 :hydrogen atom, an alkylthio group; R 11 : hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X 1 : halogen atom, a hydrogen atom; A 1 : nitrogen atom, C-X 2 ; X 2 : hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A 2 , A 3 :>C═C (-A 1 ═)—N(—R 9 )—, >N—C (-A 1 >)═C(—R 9 )—; R 10 and R 9 or R 9 and X 2 may be integrated to for a ring structure; and Y: hydrogen atom, ester forming group.

  本发明提供了一种喹诺酮衍生物，其具有强效的抗菌活性，可用于治疗包括耐药菌株在内的各种细菌感染。该化合物的结构式如下：其中R1为可选的取代芳基，其盐或水合物。在公式中，R2、R3：氢原子、烷基；R4、R5、R6：氢原子、羟基、卤素原子、氨基甲酰基、烷基、烷氧基、烷硫基；R7、R8：氢原子、烷基；R9：烷基、烯基、卤代烷基、环烷基、芳基、杂环芳基、含有1~6个碳原子的烷氧基、烷基氨基；R10：氢原子、烷硫基；R11：氢原子、氨基、羟基、硫醇基、卤代甲基基、烷基、烯基、炔基、烷氧基；X1：卤素原子、氢原子；A1：氮原子、C-X2；X2：氢原子、氨基、卤素原子、氰基、卤代甲基基、卤代甲氧基基、烷基、烯基、炔基、烷氧基；A2、A3：>C=C(-A1H)-N(-R9)-、>N-C(-A1>)=CH(-R9)-；R10和R9或R9和X2可以结合形成环状结构；Y：氢原子、酯形成基。
• Cis-substituted aminocycloalkylpyrrolidine derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20020077345A1

  公开（公告）日：2002-06-20

  Antimicrobial agents being excellent in antimicrobial activity and safety. Compounds represented by formula (I), its. salts and hydrates thereof: 1 wherein R 1 represents a hydrogen atom or an alkyl group; R 2 represents a hydrogen atom or an alkyl group; R 3 and R 5 , each represents a hydrogen atom; R 4 represents a hydroxyl group, a halogen atom, a carbamoyl group, an alkyl group, an alkoxyl group or an alkylthio group; R 6 and R 7 , each independently represents a hydrogen atom or an alkyl group; n is an integer of from 1 to 3; R 4 and the substituent on the pyrrolidine ring of the following formula: 2 are located in the cis-configuration; and Q represents a partial structure represented by the following formula: 3

  抗微生物制剂在抗微生物活性和安全性方面表现出色。由式（I）表示的化合物及其盐和水合物：其中R1表示氢原子或烷基；R2表示氢原子或烷基；R3和R5各表示氢原子；R4表示羟基、卤原子、氨基甲酰基、烷基、烷氧基或烷硫基；R6和R7各自独立地表示氢原子或烷基；n为1至3的整数；R4和以下式子中吡咯烷环上的取代基：2位于顺式构型；Q表示以下式子所表示的部分结构：3。
• Substituted Pyrrolidine Derivative
  申请人：Takahashi Hisashi

  公开号：US20080045520A1

  公开（公告）日：2008-02-21

  The present invention contemplates provision of a quinolone antibacterial agent and a drug for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g., convulsion), and which exhibit higher safety. A compound represented by the following formula (I): a salt of the compound, or a hydrate of the compound or the salt; and an antibacterial drug and an infectious disease treating drug containing the compound as an active ingredient.

  本发明考虑提供一种喹诺酮类抗菌剂和用于治疗传染病的药物，其具有强大的抗菌活性和更高的选择性毒性，针对革兰氏阳性和阴性细菌，不会引起副作用（例如，惊厥），并且表现出更高的安全性。化合物的公式如下（I）：化合物的盐，或化合物或盐的水合物；以及含有该化合物作为活性成分的抗菌药物和传染病治疗药物。
• SUBSTITUTED PYRROLIDINE DERIVATIVE
  申请人：TAKAHASHI Hisashi

  公开号：US20110166131A1

  公开（公告）日：2011-07-07

  A quinolone antibacterial compound, or a salt or hydrate of the compound, for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g., convulsion), which exhibit higher safety, and which has a structure of formula (I):

  一种喹诺酮类抗菌化合物，或其盐或水合物，用于治疗感染性疾病，具有强效的抗菌活性和对革兰氏阳性和阴性菌具有更高的选择性毒性，不会引起副作用（如惊厥），具有更高的安全性，其结构式为（I）：