1-[4-(2-methoxyethenyl)-phenyl]-ethanone | 1260177-17-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(2-methoxyethenyl)-phenyl]-ethanone
• 英文别名: 1-[4-[(Z)-2-methoxyethenyl]phenyl]ethanone
• CAS: 1260177-17-0
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: CQOHRCLUMVIESV-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.51
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  甲醇 、 4-乙炔基苯乙酮 在 dicarbonyl(2-methyl-8-quinolinolato)rhodium 作用下， 以 2,4-滴二甲胺盐 为溶剂， 反应 48.0h， 生成 1-[4-(2-methoxyethenyl)-phenyl]-ethanone 、 1-[4-(2-methoxyethenyl)-phenyl]-ethanone
  参考文献：
  名称：

  Rhodium-Catalyzed Anti-Markovnikov Intermolecular Hydroalkoxylation of Terminal Acetylenes

  摘要：

  We report here the first transition-metal-catalyzed anti-Markovnikov intermolecular hydroalkoxylation of terminal acetylenes to give enol ethers in high yields without using bases. Arylacetylenes as well as alkenyl- and alkylacetylenes were coupled with aliphatic alcohols, and the products were obtained with high Z selectivity in most cases. Effective catalysts were 8-quinolinolato rhodium complexes, which are structurally simple but have been relatively unexplored as catalysts.

  DOI：

  10.1021/ja1097385