α-CD-BIBB | 1257082-45-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-CD-BIBB
• CAS: 1257082-45-3
• 化学式: C₄₀H₆₅BrO₃₁
• 分子量: 1121.84
• InChiKey: BWAOSZWCAASANK-JLIRPUMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.33
• 重原子数：
  72.0
• 可旋转键数：
  8.0
• 环数：
  22.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  480.97
• 氢给体数：
  17.0
• 氢受体数：
  31.0

反应信息

• 作为产物：
  描述：

  2-溴-2-甲基丙酰溴 、 α-环糊精 在 吡啶 作用下， 以 氯仿 为溶剂， 反应 24.5h， 生成 α-CD-BIBB
  参考文献：
  名称：

  三嵌段共聚物和α-环糊精自组装的聚伪轮烷的原子转移自由基聚合的热敏超分子水凝胶

  摘要：

  摘要我们报道了一种新的具有可调交联网络的热敏性超分子水凝胶，该凝胶以原子转移自由基聚合中的大假引发剂和聚乙二醇二丙烯酸酯（PEGDA）为桥单元，以聚伪轮烷（PPRs）为大分子引发剂。通过超分子自组装α-环糊精或2-溴异丁酰溴改性的α-环糊精（α-CD-BIBB）和F127与溴丙酰溴末端的三嵌段共聚物制备PPR。超分子水凝胶具有包合物（ICs）的晶体结构和热敏性能。添加单官能甲基丙烯酸2-羟乙酯（HEMA）可以增强胶凝作用。溶胀率（SR）主要受α-CD或改性α-CD，HEMA和PEGDA浓度的影响。发现引入α-CD可以降低水凝胶的SR，而引入α-CD-BIBBs可以改善SR。同时，通过调节HEMA的浓度来调节凝胶化。水凝胶的SR随PEGDA浓度的增加而增加，但随HEMA的增加而降低。在20至50°C的温度范围内，水凝胶的温度敏感性主要受凝胶状态控制。PHEMA链的引入降低了网络的温度响应性。

  DOI：

  10.1016/j.reactfunctpolym.2012.12.001

文献信息

• Sliding-Graft Interpenetrating Polymer Networks from Simultaneous “Click Chemistry” and Atom Transfer Radical Polymerization
  作者：Fang Yao、LiQun Xu、Guo-Dong Fu、BaoPing Lin

  DOI：10.1021/ma102039n

  日期：2010.12.14

  In this work, a kind of semi-interpenetrating polymer network (s-IPN) with unique molecular structures, poly(ethylene glycol) (PEG) network with movable sliding-grafted poly(2-hydroxyethyl methacrylate) (PHEMA) (s-IPN-PEG/alpha-CD-sg- PHEMA), were first reported. s-IPN-PEG/alpha-CD-sg-PHEMAs were prepared by simultaneous "click chemistry" and atom transfer radical polymerization (ATRP) of a mixture of poly(ethylene glycol)-diazide/bromobutyryloxy alpha-cyclodextrin inclusion complex (N-3-PEG-N-3/(alpha-CD-BIBB)(m)), tetrakis(2-propynyloxymethyl) methane (TMOP), CuBr, pentamethyldiethylenetriamine (PMDETA), HEMA and DMF. Attributable to the controlled characters of ATRP and the quantitative yields of "click chemistry", the prepared s-IPN-PEG/alpha-CD-sg-PHEMAs have the well-defined PEG networks, as well as uniform and tunable sliding-grafted PHEMA chains. The length of sliding-grafted PHEMA of the s-IPN-PEG/alpha-CD-sg-PHEMA can be regulated by changing polymerization times. The molecular structures, and physical and thermal properties of the s-IPN-PEG/alpha-CD-sg-PHEMA were studied by FTIR, H-1 NMR, XPS, TGA, and DSC measurements. The s-IPN-PEG/alpha-CD-sg-PHEMAs exhibit good physical and mechanical properties. Most important, comparing to classical semi-IPN, the diffusion of interpenetrated PHEMA from s-IPN-PEG/alpha-CD-sg-PHEMA was largely prevented for a long time solvent immersion because the PHEMA brushes were fixed on PEG networks. The sliding-grafted PHEMA chains afford functionalities to the bulk and surface of s-IPN-PEG and could potentially be used as carriers of genes and drugs.