2-((3-aminopropyl)(pyridin-2-ylmethyl)amino)ethanol | 1430225-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-((3-aminopropyl)(pyridin-2-ylmethyl)amino)ethanol
• 英文别名: 2-[3-Aminopropyl(pyridin-2-ylmethyl)amino]ethanol
• CAS: 1430225-84-5
• 化学式: C₁₁H₁₉N₃O
• 分子量: 209.291
• InChiKey: RJBJXUNBXBNDBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  62.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  水杨醛 、 cadmium(II) perchlorate hexahydrate 、 2-((3-aminopropyl)(pyridin-2-ylmethyl)amino)ethanol 以 甲醇 为溶剂， 反应 12.0h， 以84%的产率得到
  参考文献：
  名称：

  Synthesis and characterization of mononuclear and dimeric Ni(II), Cu(II) and Cd(II) Schiff base complexes with two new asymmetrical tripodal amines. Crystal structures of Ni(II) and Cd(II) complexes and their antibacterial studies

  摘要：

  Two new tripodal amines, 2-[(2-aminoethyl)-pyridin-2-ylmethyl-amino]ethanol (1) and 2-[(3-aminopropyl)-pyridin-2-ylmethyl-amino]ethanol (2) have been prepared. These have been used to synthesis some new Schiff base complexes by template condensation with various aldehydes in the presence of Ni(II) and Cd(II) metal ions in methanol. Five new mononuclear complexes [NiL1](ClO4), [ZnL1(ClO4), [CuL1](ClO4), [NiL2](ClO4), [NiL3](ClO4), and four new dimeric complexes [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN, [NiL5](2) (ClO4)(2), [NiL6](2)(ClO4)(2) and [CdL6](2)(ClO4)(2) have been synthesized. All the complexes have been characterized using spectroscopic methods and the crystal structure of [NiL1](ClO4), [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3) CN and [CdL6](2)(ClO4)(2) were confirmed by single crystal X-ray diffraction studies. It is worth mentioning that as the chain length increases, dimeric complexes are obtained instead of mononuclear ones. Single crystal X-ray structure analysis showed that in the mononuclear Ni(II) complex, [NiL1](ClO4), the Ni(II) ion is in a distorted tetrahedral environment whilst in [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN and [CdL6](2)(ClO4)(2), two distorted octahedral Ni(II) or Cd(II) ions are bridged asymmetrically by a pair of phenoxido groups. Also, the antibacterial activity of the synthesized Ni(II) complexes against Escherichia coli (Lio), Serratia marcescens (PTCC 1330), Staphylococcous aureus (ATCC 6633), and Proteus vulgaris (Lio) was screened. All Ni(II) complexes showed antibacterial effects and [NiL1](ClO4), [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN and [NiL6](2)(ClO4)(2) are more effective against E. coli. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.07.027
• 作为产物：
  描述：

  吡啶-2-甲醛 在 sodium tetrahydroborate 、 potassium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 60.0h， 生成 2-((3-aminopropyl)(pyridin-2-ylmethyl)amino)ethanol
  参考文献：
  名称：

  Synthesis and characterization of mononuclear and dimeric Ni(II), Cu(II) and Cd(II) Schiff base complexes with two new asymmetrical tripodal amines. Crystal structures of Ni(II) and Cd(II) complexes and their antibacterial studies

  摘要：

  Two new tripodal amines, 2-[(2-aminoethyl)-pyridin-2-ylmethyl-amino]ethanol (1) and 2-[(3-aminopropyl)-pyridin-2-ylmethyl-amino]ethanol (2) have been prepared. These have been used to synthesis some new Schiff base complexes by template condensation with various aldehydes in the presence of Ni(II) and Cd(II) metal ions in methanol. Five new mononuclear complexes [NiL1](ClO4), [ZnL1(ClO4), [CuL1](ClO4), [NiL2](ClO4), [NiL3](ClO4), and four new dimeric complexes [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN, [NiL5](2) (ClO4)(2), [NiL6](2)(ClO4)(2) and [CdL6](2)(ClO4)(2) have been synthesized. All the complexes have been characterized using spectroscopic methods and the crystal structure of [NiL1](ClO4), [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3) CN and [CdL6](2)(ClO4)(2) were confirmed by single crystal X-ray diffraction studies. It is worth mentioning that as the chain length increases, dimeric complexes are obtained instead of mononuclear ones. Single crystal X-ray structure analysis showed that in the mononuclear Ni(II) complex, [NiL1](ClO4), the Ni(II) ion is in a distorted tetrahedral environment whilst in [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN and [CdL6](2)(ClO4)(2), two distorted octahedral Ni(II) or Cd(II) ions are bridged asymmetrically by a pair of phenoxido groups. Also, the antibacterial activity of the synthesized Ni(II) complexes against Escherichia coli (Lio), Serratia marcescens (PTCC 1330), Staphylococcous aureus (ATCC 6633), and Proteus vulgaris (Lio) was screened. All Ni(II) complexes showed antibacterial effects and [NiL1](ClO4), [NiL4](2)(ClO4)(2)center dot 1.5H(2)O center dot 0.5CH(3)CN and [NiL6](2)(ClO4)(2) are more effective against E. coli. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.07.027

文献信息

• Probing the effect of arm length and inter- and intramolecular interactions in the formation of Cu(<scp>ii</scp>) complexes of Schiff base ligands derived from some unsymmetrical tripodal amines
  作者：Hassan Keypour、Maryam Shayesteh、Sadegh Salehzadeh、Sébastien Dhers、Farahnaz Maleki、Hüseyin Ünver、Nefise Dilek

  DOI：10.1039/c5nj01318f

  日期：——

  The syntheses of two previously known, 2-((2-aminoethyl)(pyridin-2-ylmethyl)amino)ethanol (1) and 2-((3-aminopropyl)(pyridin-2-ylmethyl)amino)ethanol (2), and four new unsymmetrical N-capped tripodal amines, 2-((4-aminobutyl)(pyridin-2-ylmethyl)amino)ethanol (3), 3-((2-aminoethyl)(pyridin-2-ylmethyl)amino)propan-1-ol (4), 3-((3-aminopropyl)(pyridin-2-ylmethyl)amino)propan-1-ol (5) and 3-((4-aminob

  两种先前已知的2-（（2-氨基乙基）（吡啶-2-基甲基）氨基）乙醇（1）和2-（（3-氨基丙基）（吡啶-2-基甲基）氨基）乙醇（2）的合成以及四种新的不对称N封端的三脚架胺，2-（（4-氨基丁基）（吡啶-2-基甲基）氨基）乙醇（3），3-（（2-氨基乙基）（吡啶-2-基甲基）氨基）丙-1-醇（4），3-（（3-氨基丙基）（吡啶-2-基甲基）氨基）丙-1-醇（5）和3-（（4-氨基丁基）（吡啶-2-基甲基）报道了氨基）丙-1-醇（6）。配体（3-4）的臂长，3-羟丙基或丁氨基比以前使用的类似物（2-羟乙基臂，乙氨基臂或丙氨基臂1和3）长。2）。所有六种三元胺1-6均配有2-甲基吡啶基臂和乙基氨基臂（1和4），丙基氨基臂（2和5）或丁基氨基臂（3和6）。在Cu（II）金属离子存在下，新的胺3–6已与2-羟基-1-萘醛和水杨醛（及其衍生物）进行锅缩合反应，生成了一系列新的单核络合物， [M II