3-(4-fluorophenylsulfonyl)-8-(piperidin-4-yl)quinoline | 1064653-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(4-fluorophenylsulfonyl)-8-(piperidin-4-yl)quinoline
• 英文别名: 3-(4-Fluorophenyl)sulfonyl-8-piperidin-4-ylquinoline
• CAS: 1064653-70-8
• 化学式: C₂₀H₁₉FN₂O₂S
• 分子量: 370.447
• InChiKey: OYMONCUVVJQKIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
  申请人：Turner Sean Colm

  公开号：US20110009380A1

  公开（公告）日：2011-01-13

  The present invention relates to novel quinoline compounds. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT 6 receptor. wherein R is a moiety of the formula wherein A, R 1 to R 4 are as defined in the claims and the specification, n is 0, 1 or 2; m is 0, 1, 2 or 3; R a , R b are independently selected from the group consisting of halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C(O)R aa , C(O)NR cc R bb and NR cc R bb ; X is CH 2 , C(O), S, S(O) or S(O) 2 ; which is located in the 3- or 4-position of the quinoline ring; Ar is a radical Ar 1 , Ar 2 —Ar 3 or Ar 2 —O—Ar 3 , wherein Ar 1 , Ar 2 and Ar 3 are each independently selected from the group consisting of aryl or hetaryl wherein aryl or hetaryl moieties may be unsubstituted or may carry 1, 2, 3 substituents R x , wherein and physiologically tolerated acid addition salts and the N-oxides thereof.

  本发明涉及新的喹啉化合物。这些化合物具有有价值的治疗特性，特别适用于治疗对5-羟色胺5-HT6受体调节有反应的疾病。其中R是一个分子式为的基团，在该式中，A、R1至R4如权利要求和说明书中所定义，n为0、1或2，m为0、1、2或3，Ra、Rb独立地选自卤素、CN、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基、C（O）Raa、C（O）NRccRbb和NRccRbb的群；X为CH2、C（O）、S、S（O）或S（O）2，位于喹啉环的3-或4-位；Ar是一个基团Ar1、Ar2-Ar3或Ar2-O-Ar3，其中Ar1、Ar2和Ar3分别独立地选自苯基或杂环芳基，其中苯基或杂环芳基基团可以未被取代或可以携带1、2、3个取代基Rx，其中和生理上可耐受的酸加合盐和其N-氧化物。
• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DIDORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
  申请人：Abbott GmbH & Co. KG

  公开号：EP2139880A1

  公开（公告）日：2010-01-06
• US8242102B2
  申请人：——

  公开号：US8242102B2

  公开（公告）日：2012-08-14
• [EN] QUINOLINE COMPOUNDS SUITABLE FOR TREATING DIDORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR<br/>[FR] COMPOSÉS QUINOLÉINES APPROPRIÉS POUR LE TRAITEMENT DE TROUBLES QUI RÉPONDENT À UNE MODULATION DU RÉCEPTEUR 5-HT6 DE LA SÉROTONINE
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2008116831A1

  公开（公告）日：2008-10-02

  [EN] The present invention relates to novel quinoline compounds. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT₆ receptor. formula (I) wherein R is a moiety of the formula (R) wherein A, R¹ to R⁴ are as defined in the claims and the specification, n is 0, 1 or 2; m is 0, 1, 2 or 3; R^a, R^b are independently selected from the group consisting of halogen, CN, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C(O)R^aa, C(O)NR^ccR^bb and NR^ccR^bb; X is CH₂, C(O), S, S(O) or S(O)₂; which is located in the 3- or 4-position of the quinoline ring; Ar is a radical Ar¹, Ar²-Ar³ or Ar²-O-Ar³, wherein Ar¹, Ar² and Ar³ are each independently selected from the group consisting of aryl or hetaryl wherein aryl or hetaryl moieties may be unsubstituted or may carry 1, 2, 3 substituents R^x, wherein and physiologically tolerated acid addition salts and the N-oxides thereof.
  [FR] La présente invention porte sur de nouveaux composés quinoléines. Les composés possèdent de précieuses propriétés thérapeutiques et sont particulièrement appropriés pour le traitement de maladies qui répondent à une modulation de récepteur 5-HT₆ de la sérotonine. formule (I) dans laquelle R est une fraction de la formule (R) dans laquelle A, R¹ à R⁴ sont tels que définis dans les revendications et la description, n vaut 0, 1 ou 2; m vaut 0, 1, 2 ou 3, R^a, R^b sont choisis indépendamment dans le groupe constitué par halogène, CN, alkyle en C₁-C₄, haloalkyle en C₁-C₄, alcoxy en C₁-C₄, haloalcoxy en C₁-C₄, C(O)R^aa, C(O)NR^ccR^bb et NR^ccR^bb; X représente CH₂, C(O), S, S(O) or S(O)₂