4-肼基-2-甲基喹啉盐酸盐(1:1) | 61760-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-肼基-2-甲基喹啉盐酸盐(1:1)
• 英文名称: 4-hydrazino-2-methylquinoline hydrochloride
• 英文别名: (2-methyl-[4]quinolyl)-hydrazine; hydrochloride；(2-Methyl-[4]chinolyl)-hydrazin; Hydrochlorid；(2-methylquinolin-4-yl)hydrazine;hydrochloride
• CAS: 61760-54-1
• 化学式: C₁₀H₁₁N₃*ClH
• 分子量: 209.678
• InChiKey: VJHGSVNMZWGJNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.9
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-肼基-2-甲基喹啉盐酸盐(1:1) 在 水 作用下， 以92%的产率得到4-肼基-2-甲基喹啉
  参考文献：
  名称：

  Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines

  摘要：

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.

  DOI：

  10.1134/s107042801003022x
• 作为产物：
  描述：

  4-氯喹哪啶 在 盐酸 、 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 以87%的产率得到4-肼基-2-甲基喹啉盐酸盐(1:1)
  参考文献：
  名称：

  Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines

  摘要：

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.

  DOI：

  10.1134/s107042801003022x

文献信息

• WO2007/27842
  申请人：——

  公开号：——

  公开（公告）日：——
• Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard–quinoline conjugates having a urea or hydrazinecarboxamide linker
  作者：Rajesh Kakadiya、Huajin Dong、Amit Kumar、Dodia Narsinh、Xiuguo Zhang、Ting-Chao Chou、Te-Chang Lee、Anamik Shah、Tsann-Long Su

  DOI：10.1016/j.bmc.2010.01.061

  日期：2010.3

  A series of N-mustard-quinoline conjugates bearing a urea or hydrazinecarboxamide linker was synthesized for antitumor evaluation. The in vitro cytotoxicity studies revealed that compounds with hydrazinecarboxamide linkers were generally more cytotoxic than the corresponding urea counterparts in inhibiting human lymphoblastic leukemia and various solid tumor cell growths in culture. The therapeutic efficacy against human tumor xenografts in animal model was studied. It was shown that complete tumor remission in nude mice bearing human breast carcinoma MX-1 xenograft by 17a, i and 18c, d was achieved. In the present study, it was revealed that both linkers are able to lower the chemically reactive N-mustard pharmacophore and thus the newly synthesized conjugates possess a long half-life in rat plasma. Moreover, the new N-mustard derivatives are able to induce DNA cross-linking either by modified comet assay or by alkaline agarose gel shift assay. (C) 2010 Elsevier Ltd. All rights reserved.
• ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES
  申请人：Bayer HealthCare, LLC

  公开号：EP1928455A1

  公开（公告）日：2008-06-11
• [EN] ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES<br/>[FR] DERIVES D'ANILINOPYRAZOLE UTILISES DANS LE TRAITEMENT DU DIABETE
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2007027842A1

  公开（公告）日：2007-03-08

  [EN] The present invention relates to anilinopyrazole compounds of formula (1) in which R³ represents an aromatic 5- or 6-membered heteroaromatic ring which is optionally fused to phenyl, said heterocycle or fused heterocycle is optionally substituted, X represents a carboxylic acid, ester or amide, or sulfonamide, and the remaining groups are as defined in the text. It also relates to pharmaceutical compositions containing these materials and, and methods for treating diabetes and related disorders using these materials.
  [FR] La présente invention concerne des composés d'anilinopyrazole représentés par la formule (I) dans laquelle R³ désigne un noyau hétéroaromatique à 5 ou 6 chaînons qui est éventuellement fusionné à phényle, ledit hétérocycle ou hétérocycle fusionné étant éventuellement substitué, X désigne acide carboxylique, ester ou amide, ou sulfonamide et les groupes restants sont tels que définis dans la description. Cette invention concerne également des compositions pharmaceutiques contenant ces matériaux ainsi que des méthodes permettant de traiter le diabète et des troubles associés à l'aide de ces matériaux.
• Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines
  作者：A. A. Avetisyan、I. L. Aleksanyan、L. P. Ambartsumyan

  DOI：10.1134/s107042801003022x

  日期：2010.3

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.