N-[5-(5-氰基-3-噻吩基)-2-甲基苯基]-4-甲氧基苯磺酰胺 | 1233948-61-2

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[5-(5-氰基-3-噻吩基)-2-甲基苯基]-4-甲氧基苯磺酰胺
• 英文名称: N-[5-(5-cyano-thiophen-3-yl)-2-methyl-phenyl]-4-methoxy-benzenesulfonamide
• 英文别名: N-[5-(5-cyanothiophen-3-yl)-2-methylphenyl]-4-methoxybenzenesulfonamide
• CAS: 1233948-61-2
• 化学式: C₁₉H₁₆N₂O₃S₂
• 分子量: 384.48
• InChiKey: STJKZARVVAISJM-UHFFFAOYSA-N

物化性质

• 沸点：
  548.1±60.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO:36.0(最大浓度 mg/mL);93.64(最大浓度 mM)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

制备方法与用途

生物活性

EL102是HIF1α 的抑制剂，能够抑制微管蛋白聚合和减少它的稳定性。

文献信息

• [EN] COMPOSITION COMPRISING DOCETAXEL<br/>[FR] COMPOSITION COMPRENANT DU DOCÉTAXEL
  申请人：ELARA PHARMACEUTICALS GMBH

  公开号：WO2012130314A1

  公开（公告）日：2012-10-04

  The present invention relates to a composition comprising docetaxel or a solvate thereof and a phenylsulfonamide compound of the formula (I) as described herein. The invention also relates to said composition for use as a medicament, especially for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, to the use of said composition for preparing a medicament for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, and to a method for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, by administering said composition. wherein R1 is selected from C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy; R2 is selected from hydrogen and C1-C3-alkyl; and R3 is selected from C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy.