N-(5-chloro-2-methylphenyl)-4-hydroxy-4-(3-methoxyphenyl)-2-oxobut-3-enamide | 900308-84-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-(5-chloro-2-methylphenyl)-4-hydroxy-4-(3-methoxyphenyl)-2-oxobut-3-enamide
• CAS: 900308-84-1
• 化学式: C₁₈H₁₆ClNO₄
• 分子量: 345.8
• InChiKey: ARTVILCEXNCVIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SMALL MOLECULES FOR DISRUPTING THE SUPER ELONGATION COMPLEX AND INHIBITING TRANSCRIPTION ELONGATION FOR CANCER THERAPY<br/>[FR] PETITES MOLÉCULES PERMETTANT DE PERTURBER LE COMPLEXE DE SUPER-ALLONGEMENT ET D'INHIBER L'ALLONGEMENT DE LA TRANSCRIPTION POUR UNE CANCÉROTHÉRAPIE
  申请人：UNIV NORTHWESTERN

  公开号：WO2019183373A1

  公开（公告）日：2019-09-26

  Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.

  本文揭示了可用于抑制RNA聚合酶II（Pol II）转录的化合物，特别是破坏超级延伸复合物（SEC）的化合物。这些化合物可用于制备药物组合物和治疗与SEC生物活性相关的疾病和紊乱的方法，特别是与高水平表达SEC依赖基因相关的促进、支持或其他对疾病或紊乱必要的疾病和紊乱，如癌症。
• SMALL MOLECULES FOR DISRUPTING THE SUPER ELONGATION COMPLEX AND INHIBITING TRANSCRIPTION ELONGATION FOR CANCER THERAPY
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20210094907A1

  公开（公告）日：2021-04-01

  Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.