4-Acetyl-2-nitrosobenzaldehyde | 1240386-36-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Acetyl-2-nitrosobenzaldehyde
• CAS: 1240386-36-0
• 化学式: C₉H₇NO₃
• 分子量: 177.159
• InChiKey: UCDQNOCDUQQUHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Acetyl-2-nitrosobenzaldehyde 、 苄胺 以 乙腈 为溶剂， 反应 0.17h， 以33 mg的产率得到1-[3-(benzylimino)-1,3-dihydro-2,1-benzisoxazol-6-yl]ethanone
  参考文献：
  名称：

  Orthogonal Photocleavage of a Monochromophoric Linker

  摘要：

  The 4-acetyl-2-nitrobenzyl moiety, substituted in both benzylic and phenacyl positions with leaving groups, has been proposed as a monochromophoric photocleavable linker. The attached groups can be disconnected selectively and orthogonally upon irradiation.

  DOI：

  10.1021/ja1047736
• 作为产物：
  描述：

  1-{4-[(苄氧基)甲基]-3-硝基苯基}乙酮 以 乙腈 为溶剂， 反应 0.75h， 生成 4-Acetyl-2-nitrosobenzaldehyde 、 苯甲醇
  参考文献：
  名称：

  Orthogonal Photocleavage of a Monochromophoric Linker

  摘要：

  The 4-acetyl-2-nitrobenzyl moiety, substituted in both benzylic and phenacyl positions with leaving groups, has been proposed as a monochromophoric photocleavable linker. The attached groups can be disconnected selectively and orthogonally upon irradiation.

  DOI：

  10.1021/ja1047736

文献信息

• 1H-Quinazoline-2,4-Diones
  申请人：Allgeier Hans

  公开号：US20080153836A1

  公开（公告）日：2008-06-26

  The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R 1 and R 2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.

  本发明涉及公式（I）的1H-喹唑啉-2,4-二酮，其中R1和R2如规范中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。此外，还揭示了制造公式（I）化合物的中间体和包含公式（I）化合物的组合物。
• 1H-QUINAZ0LINE-2,4-DIONES
  申请人：ALLGEIER Hans

  公开号：US20100144747A1

  公开（公告）日：2010-06-10

  The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R 1 and R 2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.

  本发明涉及式(I)的1H-喹唑啉-2,4-二酮，其中R1和R2如规范中所定义，它们的制备，它们作为药物的用途以及包含它们的制药组合物。此外，还披露了制备式(I)化合物的中间体和包含式(I)化合物的组合物。
• US7655666B2
  申请人：——

  公开号：US7655666B2

  公开（公告）日：2010-02-02
• US8012988B2
  申请人：——

  公开号：US8012988B2

  公开（公告）日：2011-09-06
• Orthogonal Photocleavage of a Monochromophoric Linker
  作者：Laxminarayana Kammari、Tomáš Šolomek、Bokolombe Pitchou Ngoy、Dominik Heger、Petr Klán

  DOI：10.1021/ja1047736

  日期：2010.8.25

  The 4-acetyl-2-nitrobenzyl moiety, substituted in both benzylic and phenacyl positions with leaving groups, has been proposed as a monochromophoric photocleavable linker. The attached groups can be disconnected selectively and orthogonally upon irradiation.