N-1,4-dioxaspiro[4.5]dec-8-yl-4-methyl-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide | 880270-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-1,4-dioxaspiro[4.5]dec-8-yl-4-methyl-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide
• 英文别名: N-(1,4-dioxaspiro[4.5]decan-8-yl)-4-methyl-3-(quinolin-4-ylmethylamino)thiophene-2-carboxamide
• CAS: 880270-51-9
• 化学式: C₂₄H₂₇N₃O₃S
• 分子量: 437.563
• InChiKey: MZYDRIRNAYARAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• (Spirocyclylamido)aminothiophene compounds
  申请人：Li An-Hu

  公开号：US20060063791A1

  公开（公告）日：2006-03-23

  Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, R 1 , X and Y are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

  由式(I)表示的化合物：或其药学上可接受的盐或N-氧化物，其中A、R1、X和Y在此处定义，对于治疗肿瘤和癌症如肥大细胞增多症/肥大细胞白血病、胃肠道间质瘤（GIST）、生殖细胞肿瘤、小细胞肺癌（SCLC）、鼻窦自然杀伤/ T-细胞淋巴瘤、睾丸癌（精原细胞瘤）、甲状腺癌、恶性黑色素瘤、卵巢癌、腺样囊性癌、急性髓细胞白血病（AML）、乳腺癌、儿童T细胞急性淋巴细胞白血病、神经母细胞瘤、肥大细胞白血病、血管肉瘤、间变性大细胞淋巴瘤、子宫内膜癌和前列腺癌具有用处。
• (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO-ONCOGENE INHIBITORS
  申请人：OSI Pharmaceuticals, Inc.

  公开号：EP1817310A1

  公开（公告）日：2007-08-15
• [EN] (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO- ONCOGENE INHIBITORS<br/>[FR] COMPOSÉS (SPIROCYCLYLAMIDO)AMINOTHIOPHÈNES EN TANT QU'INHIBITEURS DU PROTO-ONCOGÈNE c-KIT
  申请人：OSI PHARM INC

  公开号：WO2006034015A1

  公开（公告）日：2006-03-30

  Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, R1, X and Y are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.