1-乙基环己烷-顺式-1,2-二醇 | 58016-18-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-乙基环己烷-顺式-1,2-二醇
• 英文名称: 1-ethylcyclohexane-cis-1,2-diol
• 英文别名: (+/-)-1r-ethyl-cyclohexanediol-(1.2t)；(+/-)-1r-Aethyl-cyclohexandiol-(1.2t)；cis-1-Ethyl-cyclohexan-1,2-diol；(1S,2R)-1-ethylcyclohexane-1,2-diol
• CAS: 58016-18-5；58016-19-6；101870-44-4
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: MRKXWPWFBFEBII-SFYZADRCSA-N

物化性质

• 熔点：
  81 °C
• 沸点：
  240.1±8.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙基环己烷-顺式-1,2-二醇 、 邻甲基氯化苄 在 sodium hydroxide 作用下， 生成
  参考文献：
  名称：

  DE2753556

  摘要：

  公开号：
• 作为产物：
  描述：

  1-vinyl-1,2-cyclohexanediol 在 platinum(IV) oxide 氢气 作用下， 以 乙醚 为溶剂， 生成 1-乙基环己烷-顺式-1,2-二醇
  参考文献：
  名称：

  Barnier,J.-P.; Conia,J.-M., Bulletin de la Societe Chimique de France, 1975, p. 1659 - 1662

  摘要：

  DOI：

文献信息

• Kinetic control in the benzylidenation of some 1-alkylcyclohexane-cis-1,2-diols
  作者：Neil Baggett、Mohammed Mosihuzzaman、John M. Webber

  DOI：10.1016/0008-6215(85)85208-3

  日期：1985.2

  Abstract Acid-catalysed benzylidenation reactions of a series of alkyl substituted derivatives of cyclohexane- cis -1,2-diol have been studied. Preferential formation of the exo -phenyl benzylidene acetal was observed in the initial kinetic phase of the reaction of the 1- tert -butyl derivative, whereas the endo -phenyl acetal was preferentially formed from other diols. This behaviour has been rationalised

  摘要研究了环己烷-顺式-1,2-二醇的一系列烷基取代衍生物的酸催化的亚苄基化反应。在1-叔丁基衍生物的反应的初始动力学阶段观察到外苯基苯基亚苄基缩醛的优选形成，而内苯基缩醛优选由其他二醇形成。通过考虑氧碳鎓离子中间体的构象的可能稳定性，使这种行为合理化。
• 842. Stereochemistry of cyclohexane derivatives. Part IV. Some secondary tertiary 1 : 2-diols
  作者：P. R. Jefferies、B. Milligan

  DOI：10.1039/jr9560004384

  日期：——
• Reactions to tick antitoxin serum and the role of atropine in treatment of dogs and cats with tick paralysis caused by Ixodes holocyclus: a pilot survey
  作者：RB ATWELL、FE CAMPBELL

  DOI：10.1111/j.1751-0813.2001.tb12980.x

  日期：2001.6

  Objective To determine the incidence and nature of adverse reactions of dogs and cats to tick antitoxin serum and to re‐evaluate the role of atropine in the treatment of tick paralysis.Design A retrospective questionnaire of veterinarians.Procedure Questionnaires were posted to 320 veterinarians in tick‐endemic regions of Australia. Questions referred to dogs and cats treated for tick paralysis over a period of three years: the number treated, treatment protocols and adverse systemic reactions to tick antitoxin serum. Ninety completed questionnaires were returned and responses analysed.Results Veterinarians reported that approximately 3% of dogs exhibited adverse reactions immediately following treatment with tick antitoxin serum. Eighteen percent of these reactions were described as anaphylaxis, with the remaining 82% attributed to the Bezold‐Jarisch reflex. Six percent of cats treated with tick antitoxin serum reacted adversely and the majority of reactions (63%) were ascribed to the Bezold‐Jarisch reflex. Atropine was used routinely by 10% of responding veterinarians in the treatment of dogs and cats with tick paralysis. A similar number of veterinarians used atropine only in selected cases. Most veterinarians (76%) reported that they never used atropine in the treatment of tick paralysis in either dogs or cats. Within the survey population, premedication with atropine reduced the number of Bezold‐Jarisch reactions following tick antitoxin administration approximately five‐fold in dogs and four‐fold in cats.Conclusions Data from this pilot survey indicate that more cats than dogs have adverse systemic reactions to tick antitoxin serum and that the majority of these reactions in both dogs and cats could be related to the Bezold‐Jarisch reflex. The number of reactions to tick antitoxin serum in dogs and cats could be significantly reduced by the routine use of atropine prior to administration of tick antitoxin serum.