7-chloro-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-3-(phenylmethyl)-4H-pyrano[2,3-b]pyridin-4-one | 1044664-07-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 7-chloro-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-3-(phenylmethyl)-4H-pyrano[2,3-b]pyridin-4-one
• 英文别名: 3-Benzyl-7-chloro-2-[2-methyl-1-(7-oxo-1,4-diazepan-1-yl)propyl]pyrano[2,3-b]pyridin-4-one
• CAS: 1044664-07-4
• 化学式: C₂₄H₂₆ClN₃O₃
• 分子量: 439.942
• InChiKey: SBVZNYQZQCFXSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Boc-D-缬氨酸 在 氯甲酸乙酯 、 magnesium 、 三乙胺 、 三氟乙酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 、 水 为溶剂， 反应 7.92h， 生成 7-chloro-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-3-(phenylmethyl)-4H-pyrano[2,3-b]pyridin-4-one
  参考文献：
  名称：

  Compounds, compositions and methods

  摘要：

  本发明揭示了一种通过调节KSP活性治疗细胞增殖性疾病和障碍的有用化合物。

  公开号：

  US20050165089A1

文献信息

• Preparation of glycol carboxyethylmethylphosphinate
  申请人：Clariant GmbH

  公开号：US20030171466A1

  公开（公告）日：2003-09-11

  The invention relates to a process of preparing glycol carboxyethylmethylphosphinate, which comprises a) reacting elemental yellow phosphorus with methyl chloride in the presence of an alkali or alkaline earth metal hydroxide to form a mixture which includes the alkali and/or alkaline earth metal salts of methylphosphonous, phosphorous and hypophosphorous acids as main constituents, b) esterifying the methylphosphonous acid from the mixture obtained by a), c) removing the methylphosphonous ester from the mixture, d) adding the thus obtained methylphosphonous ester to an acrylic ester, e) hydrolyzing the diester thus obtained, f) esterifying the resulting carboxyethylmethylphosphinic acid with ethylene glycol directly to the glycol carboxyethylmethylphosphinate. The invention also relates to the use of the glycol carboxyethylmethylphosphinates prepared according to the invention as reactive flame retardants for polymers.

  本发明涉及一种制备乙二醇羧基乙基甲基膦酸盐的方法，包括以下步骤： a) 在碱金属或碱土金属氢氧化物的存在下，将元素黄磷与氯甲烷反应，形成包括甲基亚磷酸、亚磷酸和次亚磷酸的碱金属和/或碱土金属盐的混合物； b) 酯化步骤a）中所得混合物中的甲基亚磷酸； c) 从混合物中去除甲基亚磷酸酯； d) 将所得的甲基亚磷酸酯加入丙烯酸酯中； e) 水解所得的二酯； f) 将得到的羧基乙基甲基膦酸与乙二醇直接酯化为乙二醇羧基乙基甲基膦酸盐。 本发明还涉及根据本发明所述方法制备的乙二醇羧基乙基甲基膦酸盐作为聚合物的反应性阻燃剂的用途。
• Linear copolyester containing phosphorous, procedure for its preparation and its use as a flame-retardant additive
  申请人：GREAT LAKES CHEMICAL ITALIA S.r.l.

  公开号：EP0547701A2

  公开（公告）日：1993-06-23

  A linear copolyester is prepared by polycondensation of an aromatic bicarboxylic acid with an alkylene glycol and with a carboxyphosphinic acid or anhydride which produces monomeric units having the formula: wherein R₁ is an alkylene or phenyl radical and R₂ is an alkyl or phenyl radical. This copolyester can be used as a flame-retardant additive for organic polymers.

  通过芳香族二羧酸与亚烷基二醇和羧基膦酸或酐的缩聚反应制备线性共聚聚酯，其产生的单体单元具有如下式子 其中 R₁ 是亚烷基或苯基，R₂ 是烷基或苯基。 这种共聚聚酯可用作有机聚合物的阻燃添加剂。
• Flame-resistant polyamide, method for the production of said flame-resistant polyamide, and use of said flame-resistant polyamide
  申请人：DEUTSCHE INSTITUTE FÜR TEXTILUND FASERFORSCHUNG DENKENDORF

  公开号：US10118990B2

  公开（公告）日：2018-11-06

  The invention relates to a flame-resistant polyamide as a product of the condensation of dicarboxylic acids with diamines and with a flame-retardant phosphorus compound, which flame-resistant polyamide is characterized in that the flame-resistant polyamide FR contains, in the main chain thereof phosphinic acid amide structural units of formula (II) —PO(R1)—NH— (II) in addition to the amide structural units of formula (I) CO—NH— (I), in which formula (II) RI means hydrogen or an organic group and can differ in the individual phosphinic acid amide structural units within the main chain and that the polyamide FR achieves a relative viscosity, measured as a 1% solution in 96% sulfuric acid at 25° C., of at least 2.0 (in accordance with DIN 51562). The invention further relates to a method for producing said flame-resistant polyamide FR. In said method, one or more diamines are polycondensed with one or more dicarboxylic acids under pressure and at elevated temperature in the presence of water and with one or more diphosphinic acids and/or one or more phosphino-carboxylic acids by means of a polyamide synthesis. After the polycondensation, the pressure in the reaction chamber is reduced to less than 1 bar. The flame-resistant polyamide can be advantageously used to produce molded bodies, in particular films, components, and filaments or filament yarns.

  本发明涉及一种阻燃聚酰胺，它是二羧酸与二胺和阻燃磷化合物缩合的产物，该阻燃聚酰胺的特征在于，阻燃聚酰胺 FR 的主链中除含有式（II）-PO（R1）-NH-（II）的酰胺结构单元外，还含有式（I）CO-NH-（II）的酰胺结构单元、在其主链中，除了式(I) CO-NH- (I)的酰胺结构单元外，还含有式(II) -PO(R1)-NH- (II)的膦酸酰胺结构单元，其中式(II) RI 指氢或有机基团，在主链中的各个膦酸酰胺结构单元可以不同。,的相对粘度至少为 2.0（符合 DIN 51562 标准）。本发明还涉及一种生产上述阻燃聚酰胺 FR 的方法。在该方法中，一种或多种二胺与一种或多种二羧酸在加压和升温的条件下，在有水和一种或多种二膦酸和/或一种或多种膦羧酸存在的情况下，通过聚酰胺合成法进行缩聚。缩聚后，反应室的压力降至 1 巴以下。阻燃聚酰胺可用于生产模塑体，特别是薄膜、部件、长丝或长丝纱线。
• Polymer composition comprising phosphorus-containing linear copolyesters
  申请人：GREAT LAKES CHEMICAL ITALIA S.r.l.

  公开号：EP0547701B1

  公开（公告）日：1998-08-05
• FLAME-RETARDANT RECYCLED POLYESTER COPOLYMERS
  申请人：MONSANTO COMPANY

  公开号：EP0749459A1

  公开（公告）日：1996-12-27