3-(3-bromophenylsulfonyl)-8-iodoquinoline | 1064653-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(3-bromophenylsulfonyl)-8-iodoquinoline
• 英文别名: 3-(3-bromophenyl)sulfonyl-8-iodoquinoline
• CAS: 1064653-78-6
• 化学式: C₁₅H₉BrINO₂S
• 分子量: 474.116
• InChiKey: DKJJJRLJHMNFLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-BOC-八氢吡咯基[3,4-C]吡咯 、 3-(3-bromophenylsulfonyl)-8-iodoquinoline 在 tert-butyl 5-(3-(3-(5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 作用下， 以18 mg (12%) of the title compound were obtained as a pale yellow solid的产率得到tert-butyl 5-(3-(3-(5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
  参考文献：
  名称：

  Quinoline compounds suitable for treating disorders that respond to modulation of the serotonin-5-HT6 receptor

  摘要：

  本发明涉及公式（I）的新型喹啉化合物及其盐。这些化合物具有有价值的治疗特性，特别适用于治疗对5-HT6受体调节有反应的疾病。在公式（I）中，R是公式（R）的一个基团，其中*表示与喹啉基团的结合位点，A、B、X'、Y、Q、R1、R2、R3、R4、R5、m、n、p、q、Ra、Rb、X和Ar如权利要求1所定义。

  公开号：

  US08293913B2

文献信息

• [EN] QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR<br/>[FR] COMPOSÉS DE QUINOLÉINE APPROPRIÉS POUR TRAITER LES AFFECTIONS SENSIBLES À LA MODULATION DES RÉCEPTEURS SÉROTONINERGIQUES 5-HT6
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2009019286A1

  公开（公告）日：2009-02-12

  The present invention relates to novel quinoline compounds of the formula (I) and to the salts thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. In formula (I) R is a moiety of the formula (R) wherein * indicates the binding site to the quinolinyl radical and wherein A, B, X', Y, Q, R1, R2, R3, R4, R5, m, n, p, q, Ra, Rb, X and Ar are as defined in claim 1.

  本发明涉及公式（I）的新奎诺林化合物及其盐。这些化合物具有有价值的治疗性能，并特别适用于治疗对5-HT6受体调节产生反应的疾病。在公式（I）中，R是公式（R）的基团，其中*表示与喹啉基团的结合位点，A、B、X'、Y、Q、R1、R2、R3、R4、R5、m、n、p、q、Ra、Rb、X和Ar的定义如权利要求书中所述。
• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN-5-HT6 RECEPTOR
  申请人：Turner Sean Colm

  公开号：US20130005703A1

  公开（公告）日：2013-01-03

  The present invention relates to novel quinoline compounds of the formula (I) and to the salts thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT 6 receptor. In formula (I) R is a moiety of the formula (R) wherein * indicates the binding site to the quinolinyl radical and wherein A, B, X′, Y, Q, R 1 , R 2 , R 3 , R 4 , R 5 , m, n, p, q, R a , R b , X and Ar are as defined in claim 1 .

  本发明涉及公式（I）的新型喹啉化合物及其盐。该化合物具有有价值的治疗性能，特别适用于治疗对5-HT6受体调节有反应的疾病。在公式（I）中，R是公式（R）的基团，其中*表示与喹啉基团的结合位点，其中A、B、X'、Y、Q、R1、R2、R3、R4、R5、m、n、p、q、Ra、Rb、X和Ar如权利要求1所定义。
• Quinoline Compounds Suitable for Treating Disorders that Respond to Modulation of the Serotonin-5-HT6 Receptor
  申请人：Turner Sean Colm

  公开号：US20100292271A1

  公开（公告）日：2010-11-18

  The present invention relates to novel quinoline compounds of the formula (I) and to the salts thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5 -HT 6 receptor. In formula (I) R is a moiety of the formula (R) wherein * indicates the binding site to the quinolinyl radical and wherein A, B, X′, Y, Q, R 1 , R 2 , R 3 , R 4 , R 5 , m, n, p, q, R 1 , R b , X and Ar are as defined in claim 1.

  本发明涉及公式(I)的新型喹啉化合物及其盐。这些化合物具有有价值的治疗性质，特别适用于治疗对5-HT6受体调节有反应的疾病。在公式(I)中，R是公式(R)的一部分，其中*表示与喹啉基团的结合位点，而A、B、X'、Y、Q、R1、R2、R3、R4、R5、m、n、p、q、Rb、X和Ar的定义如权利要求书1所述。
• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
  申请人：Turner Sean Colm

  公开号：US20110009380A1

  公开（公告）日：2011-01-13

  The present invention relates to novel quinoline compounds. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT 6 receptor. wherein R is a moiety of the formula wherein A, R 1 to R 4 are as defined in the claims and the specification, n is 0, 1 or 2; m is 0, 1, 2 or 3; R a , R b are independently selected from the group consisting of halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C(O)R aa , C(O)NR cc R bb and NR cc R bb ; X is CH 2 , C(O), S, S(O) or S(O) 2 ; which is located in the 3- or 4-position of the quinoline ring; Ar is a radical Ar 1 , Ar 2 —Ar 3 or Ar 2 —O—Ar 3 , wherein Ar 1 , Ar 2 and Ar 3 are each independently selected from the group consisting of aryl or hetaryl wherein aryl or hetaryl moieties may be unsubstituted or may carry 1, 2, 3 substituents R x , wherein and physiologically tolerated acid addition salts and the N-oxides thereof.

  本发明涉及新的喹啉化合物。这些化合物具有有价值的治疗特性，特别适用于治疗对5-羟色胺5-HT6受体调节有反应的疾病。其中R是一个分子式为的基团，在该式中，A、R1至R4如权利要求和说明书中所定义，n为0、1或2，m为0、1、2或3，Ra、Rb独立地选自卤素、CN、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基、C（O）Raa、C（O）NRccRbb和NRccRbb的群；X为CH2、C（O）、S、S（O）或S（O）2，位于喹啉环的3-或4-位；Ar是一个基团Ar1、Ar2-Ar3或Ar2-O-Ar3，其中Ar1、Ar2和Ar3分别独立地选自苯基或杂环芳基，其中苯基或杂环芳基基团可以未被取代或可以携带1、2、3个取代基Rx，其中和生理上可耐受的酸加合盐和其N-氧化物。
• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DIDORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
  申请人：Abbott GmbH & Co. KG

  公开号：EP2139880A1

  公开（公告）日：2010-01-06