diethyl 2-(4-phenylthiazol-2-yl)phenyl phosphate | 1397690-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: diethyl 2-(4-phenylthiazol-2-yl)phenyl phosphate
• CAS: 1397690-17-3
• 化学式: C₁₉H₂₀NO₄PS
• 分子量: 389.412
• InChiKey: VJVIYMFFNDDLPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.04
• 重原子数：
  26.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  57.65
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  diethyl 2-(4-phenylthiazol-2-yl)phenyl phosphate 在 三甲基溴硅烷 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 8.0h， 以43%的产率得到sodium 2-(4-phenylthiazol-2-yl)phenyl phosphate
  参考文献：
  名称：

  Fluorogenic assay of alkaline phosphatase activity based on the modulation of excited-state intramolecular proton transfer

  摘要：

  A new fluorogenic substrate 1, which enables the fast and quantitative analysis of alkaline phosphatase activity, has been developed. Selective enzymatic hydrolysis of 1 instantly generated fluorescent compound 2 in aqueous media, which undergo an excited-state intramolecular proton transfer process, resulting in a remarkable fluorescence turn-on signal with an unusually large Stokes shift. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.021
• 作为产物：
  描述：

  氯磷酸二乙酯 、 2-(2-hydroxyphenyl)-4-phenylthiazole 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 48.0h， 以68%的产率得到diethyl 2-(4-phenylthiazol-2-yl)phenyl phosphate
  参考文献：
  名称：

  Fluorogenic assay of alkaline phosphatase activity based on the modulation of excited-state intramolecular proton transfer

  摘要：

  A new fluorogenic substrate 1, which enables the fast and quantitative analysis of alkaline phosphatase activity, has been developed. Selective enzymatic hydrolysis of 1 instantly generated fluorescent compound 2 in aqueous media, which undergo an excited-state intramolecular proton transfer process, resulting in a remarkable fluorescence turn-on signal with an unusually large Stokes shift. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.021