(S)-[[3-[[(Cyanoamino)[[3-methoxy-4-(5-oxazolyl)phenyl]amino]methylene]amino]phenyl]methyl]carbamic Acid Tetrahydro-3-furanyl Ester | 441756-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-[[3-[[(Cyanoamino)[[3-methoxy-4-(5-oxazolyl)phenyl]amino]methylene]amino]phenyl]methyl]carbamic Acid Tetrahydro-3-furanyl Ester
• 英文别名: [(3S)-oxolan-3-yl] N-[[3-[[N-cyano-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidoyl]amino]phenyl]methyl]carbamate
• CAS: 441756-88-3
• 化学式: C₂₄H₂₄N₆O₅
• 分子量: 476.492
• InChiKey: AMZWJMVHRUVIEY-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3-甲氧基-4-(1,3-噁唑)苯胺 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-[[3-[[(Cyanoamino)[[3-methoxy-4-(5-oxazolyl)phenyl]amino]methylene]amino]phenyl]methyl]carbamic Acid Tetrahydro-3-furanyl Ester
  参考文献：
  名称：

  Novel guanidine-Based inhibitors of inosine monophosphate dehydrogenase

  摘要：

  A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00600-5

文献信息

• [EN] METABOLISM-MODULATING AGENTS AND USES THEREFOR<br/>[FR] AGENTS DE MODULATION DU MÉTABOLISME ET UTILISATIONS ASSOCIÉES
  申请人：UNIV QUEENSLAND

  公开号：WO2006017896A1

  公开（公告）日：2006-02-23

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5' monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

  本发明旨在提供调节脂肪生成的方法和试剂。更具体地，本发明涉及能够调节次黄嘌呤-5'一磷酸脱氢酶（IMPDH）的水平或功能活性的分子，以及它们在调节脂肪细胞中脂质的积累和/或脂肪细胞前体分化为脂肪细胞方面的作用，从而用于治疗或预防与脂肪量相关的疾病，包括但不限于肥胖症、脂肪瘤、脂肪瘤病、恶病质或脂肪营养不良，或由于创伤或萎缩性条件导致的脂肪组织损失。
• METABOLISM-MODULATING AGENTS AND USES THEREFOR
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1786415A1

  公开（公告）日：2007-05-23
• Metabolism-modulating agents and uses therefor
  申请人：Whitehead Paul Jonathan

  公开号：US20060106097A1

  公开（公告）日：2006-05-18

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5′ monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
• US6420403B1
  申请人：——

  公开号：US6420403B1

  公开（公告）日：2002-07-16
• US7915255B2
  申请人：——

  公开号：US7915255B2

  公开（公告）日：2011-03-29