biphenyl-4-carboxylic acid [1-acetyl-2,2,4-trimethyl-4-(4-methylcarbamoylmethoxy-phenyl)-1,2,3,4-tetrahydroquinolin-6-yl]-amide | 717866-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: biphenyl-4-carboxylic acid [1-acetyl-2,2,4-trimethyl-4-(4-methylcarbamoylmethoxy-phenyl)-1,2,3,4-tetrahydroquinolin-6-yl]-amide
• 英文别名: N-[1-acetyl-2,2,4-trimethyl-4-[4-[2-(methylamino)-2-oxoethoxy]phenyl]-3H-quinolin-6-yl]-4-phenylbenzamide
• CAS: 717866-07-4
• 化学式: C₃₆H₃₇N₃O₄
• 分子量: 575.707
• InChiKey: KJUNLOYILJEUOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS
  申请人：Akzo Nobel N.V.

  公开号：EP1578727A2

  公开（公告）日：2005-09-28
• [EN] TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS<br/>[FR] DERIVES DE TETRAHYDROQUINOLINE
  申请人：AKZO NOBEL NV

  公开号：WO2004056779A2

  公开（公告）日：2004-07-08

  The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein Rl and R2 are H, Me; R3 is (2-6C)heterocycloalkyl(1-­4C)alkyl, (2-5C)heteroaryl(1-4C)alkyl, (6C)aryl (1-4C)alkyl, (1-4C)(di)alkylaminocarbonylamino(2-4C)alkyl, (2-­6C) heterocycloalkylcarbonylamino(2-4C)alkyl, R5-(2-4C)alkyl or R5-carbonyl(1-4C)alkyl; R4 is (2-5C)heteroaryl, (6C)aryl, (3-8C)cycloalkyl, (2-6C)heterocycloalkyl or (1-6C) alkyl and R5 is (di)(1-4C)alkylamino, (1-4C)alkoxy, amino, hydroxy, (6C)arylamino, (di)(3-4C)alkenylamino, (2-5C)heteroaryl(1-4C)alkylamino, (6C)aryl(1-4C) alkylamino, (di)[(1­-4C)alkoxy(2-4C)alkyl]amino, (di)[(1-4C)alkylamino(2-4C) alkyl]amino, (di)[amino(2-4C)alkyl]amino or (di)[hydroxy(2­-4C)alkyl]amino. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.