| 1429865-15-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1429865-15-5
• 化学式: C₁₂H₇Cl₃O₂*C₄₈H₈₀O₄₀
• 分子量: 1586.68
• InChiKey: XWUUFPRBQABDRA-SMTXKKGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.26
• 重原子数：
  105.0
• 可旋转键数：
  10.0
• 环数：
  32.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  662.66
• 氢给体数：
  25.0
• 氢受体数：
  42.0

反应信息

• 作为产物：
  描述：

  三氯生 、 γ-环糊精 以 水 为溶剂， 反应 1.0h， 以50%的产率得到
  参考文献：
  名称：

  Antibacterial Electrospun Poly(lactic acid) (PLA) Nanofibrous Webs Incorporating Triclosan/Cyclodextrin Inclusion Complexes

  摘要：

  Solid triclosan/cyclodextrin inclusion complexes (TR/CD-IC) were obtained and then incorporated in poly(lactic acid) (PLA) nanofibers via electrospinning. alpha-CD, beta-CD, and gamma-CD were tested for the formation of TR/CD-IC by a coprecipitation method; however, the findings indicated that alpha-CD could not form an inclusion complex with TR, whereas beta-CD and gamma-CD successfully formed TR/CD-IC crystals, and the molar ratio of TR to CD was found to be 1:1. The structural and thermal characteristics of TR/CD-IC were investigated by H-1 NMR, FTIR, XRD, DSC, and TGA studies. Then, the encapsulation of TR/beta-CD-IC and TR/gamma-CD-IC in PLA nanofibers was achieved. Electrospun PLA and PLA/TR nanofibers obtained for comparison were uniform, whereas the aggregates of TR/CD-IC crystals were present and distributed within the PLA fiber matrix as confirmed by SEM and XRD analyses. The antibacterial activity of these nanofibrous webs was investigated. The results indicated that PLA nanofibers incorporating TR/CD-IC showed better antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria compared to PLA nanofibers containing only TR without CD-IC. Electrospun nanofibrous webs incorporating TR/CD-IC may be applicable in active food packaging due to their very high surface area and nanoporous structure as well as efficient antibacterial property.

  DOI：

  10.1021/jf400440b