5-(1-hydroxyethyl)-1,3-thiazole-2-carboxaldehyde | 1080060-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(1-hydroxyethyl)-1,3-thiazole-2-carboxaldehyde
• 英文别名: 5-(1-hydroxyethyl)-1,3-thiazole-2-carbaldehyde
• CAS: 1080060-62-3
• 化学式: C₆H₇NO₂S
• mdl: MFCD24686875
• 分子量: 157.193
• InChiKey: JSYDCUWOVYIYKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(1-hydroxyethyl)-1,3-thiazole-2-carboxaldehyde 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 以95%的产率得到1-[2-(hydroxymethyl)-1,3-thiazol-5-yl]ethan-1-ol
  参考文献：
  名称：

  Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles

  摘要：

  A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.

  DOI：

  10.1134/s1070363215080113
• 作为产物：
  描述：

  1-[2-(1,3-dioxolan-2-yl)-1,3-thiazol-5-yl]ethan-1-ol 在 盐酸 、 水 、 碳酸氢钠 作用下， 以 丙酮 、 水 为溶剂， 反应 3.0h， 以39%的产率得到5-(1-hydroxyethyl)-1,3-thiazole-2-carboxaldehyde
  参考文献：
  名称：

  NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLIC COMPOUND

  摘要：

  本发明提供了一种由以下式（I）表示的化合物： 其中每个符号如规范中定义，或其盐。本发明的化合物具有葡萄糖激酶活性，并且可用作药物，如预防或治疗糖尿病、肥胖等的药剂，诸如此类。

  公开号：

  EP2149550A1

文献信息

• NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2149550A1

  公开（公告）日：2010-02-03

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof. The compound of the present invention has a glucokinase activity, and is useful as a medicament such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like.

  本发明提供了一种由以下式（I）表示的化合物： 其中每个符号如规范中定义，或其盐。本发明的化合物具有葡萄糖激酶活性，并且可用作药物，如预防或治疗糖尿病、肥胖等的药剂，诸如此类。
• Nitrogen-containing five-membered heterocyclic compound
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US08318746B2

  公开（公告）日：2012-11-27

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof. The compound of the present invention has a glucokinase activity, and is useful as a medicament such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like.

  本发明提供一个由公式（I）所表示的化合物：其中每个符号如规范中所定义，或其盐。本发明的化合物具有葡萄糖激酶活性，可用作药物，如预防或治疗糖尿病、肥胖症等疾病的药剂。
• Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes
  作者：V. O. Sinenko、S. R. Slivchuk、S. G. Pil’o、G. F. Raenko、V. S. Brovarets

  DOI：10.1134/s1070363216070100

  日期：2016.7

  Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.
• US8318746B2
  申请人：——

  公开号：US8318746B2

  公开（公告）日：2012-11-27
• Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles
  作者：V. O. Sinenko、S. R. Slivchuk、Ya. G. Bal’on、V. S. Brovarets

  DOI：10.1134/s1070363215080113

  日期：2015.8

  A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.