bis[di-n-butyl(3-maleimidopropionato)tin(IV)] oxide | 798575-85-6

• 英文名称: bis[di-n-butyl(3-maleimidopropionato)tin(IV)] oxide
• CAS: 798575-85-6
• 化学式: C₆₀H₉₆N₄O₁₈Sn₄
• 分子量: 1636.28
• InChiKey: PZAOYLZWSJUCNH-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  3-马来酰亚胺基丙酸 、 二正丁基氧化锡 以 氯仿 、 苯 为溶剂， 以87%的产率得到bis[di-n-butyl(3-maleimidopropionato)tin(IV)] oxide
  参考文献：
  名称：

  Biological aspects of new organotin(IV) compounds of 3-maleimidopropionic acid

  摘要：

  Four new compounds of organic mono carboxylic acid, 3-maleimidopropionic acid; with Bu2Sn(IV)(2+), Ph3Sn(IV)(+) and Cychex(3)Sn(IV)(+) having ligand to metal ratio 1:2 and 1:1 were prepared. The spectrophotometric techniques used for structure determination like H-1-, C-13- and Sn-119-NMR, FT IR and Sn-119m Mossbauer have demonstrated that the organotin(IV) moieties establish chemical bonding with the ligand through carboxylic oxygen atom. The percent CHN analyses and MS data also corroborates the spectroscopic results. During in vitro LD50, anti-fungal, anti-bacterial and anti-yeast bioassays promising results were exhibited. In vitro anti-tumour activity assays against five human tumor cell lines, MCF-7 Breast cancer-EVSA-T Breast cancer-WiDr Colon cancer-IGROV Ovarian cancer-M226 Non small cell lung cancer and anti-inflammatory screenings furnished the significant toxicities of the title complexes. In addition the triorganotin(IV) complexes were comparatively less toxic than the diorganotin(IV) complexes. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.07.049