3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester | 124930-59-2

分子结构分类

有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷

中文名称

——

中文别名

——

英文名称

3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester

英文别名

3'-azido-3'-deoxythymidine 5'-(hydrogen phosphonate)；3'-azido-3'-deoxythymidine 5'-hydrogenphosphonate；phosphazid；5'-(H-phosphonate) AZT；nikavir；[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyphosphinic acid

3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester化学式

CAS

124930-59-2

化学式

C₁₀H₁₄N₅O₆P

mdl

——

分子量

331.225

InChiKey

HXXOFKXVESEZNB-XLPZGREQSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

0.21
重原子数：

22.0
可旋转键数：

5.0
环数：

2.0
sp3杂化的碳原子比例：

0.6
拓扑面积：

159.38
氢给体数：

2.0
氢受体数：

7.0

SDS

SDS：63b6cb30e5e2961a50ab3a77faca58c3

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上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	O-ethyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate	158689-24-8	C₁₂H₁₈N₅O₆P	359.279
——	5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) H-phosphonate diester	151029-28-6	C₂₀H₂₅N₁₀O₉P	580.454
——	3'-azido-2',3'-dideoxythymidine monophosphate	29706-85-2	C₁₀H₁₄N₅O₇P	347.224
——	((2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isopropyl phosphonate	329237-18-5	C₁₃H₂₀N₅O₆P	373.305
——	1-[(2R,4S,5S)-4-azido-5-(2,2-dimethylpropoxyphosphonoyloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione	376356-94-4	C₁₅H₂₄N₅O₆P	401.359
——	O-cyclohexyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate	329237-23-2	C₁₆H₂₄N₅O₆P	413.37
——	1-[(2R,4S,5S)-4-azido-5-[[methoxy(oxido)phosphaniumyl]oxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione	158689-23-7	C₁₁H₁₆N₅O₆P	345.252
——	P-(tert-butyl)-3'-azido-3'-deoxythymidine 5'-hydrogenphosphonate	322684-70-8	C₁₄H₂₂N₅O₆P	387.332
——	O-benzyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate	244642-03-3	C₁₇H₂₀N₅O₆P	421.349
——	1-[(2R,4S,5S)-5-(1-adamantyloxyphosphonoyloxymethyl)-4-azidooxolan-2-yl]-5-methylpyrimidine-2,4-dione	322684-67-3	C₂₀H₂₈N₅O₆P	465.446
齐多夫定	3'-azido-2',3'-deoxythymidine	30516-87-1	C₁₀H₁₃N₅O₄	267.244
——	trimethyl 3'-azido-3'-deoxythymidine 5'-(diazomethylene)bisphosphonate	492433-40-6	C₁₄H₂₁N₇O₉P₂	493.31
——	1-Hydroxy-1-phenylmethylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-76-9	C₂₇H₃₁N₁₀O₁₀P	686.578
——	1-Hydroxy-1-(4-methylphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-75-8	C₂₈H₃₃N₁₀O₁₀P	700.605
——	1-Hydroxy-1-(4-chlorophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-77-0	C₂₇H₃₀ClN₁₀O₁₀P	721.023
——	1-Hydroxy-1-(4-cyanophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-78-1	C₂₈H₃₀N₁₁O₁₀P	711.588
——	1-Hydroxy-1-(4-methoxyphenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-74-7	C₂₈H₃₃N₁₀O₁₁P	716.604
——	1-Hydroxy-1-(4-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	164652-12-4	C₂₇H₃₀N₁₁O₁₂P	731.575
——	3'-azido-3'-deoxythymidin-5'-yl 4-chlorophenyl α-hydroxy(phenyl)methylphosphonate	1233510-59-2	C₂₃H₂₃ClN₅O₇P	547.892
——	1-Hydroxy-1-(3-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	166318-79-2	C₂₇H₃₀N₁₁O₁₂P	731.575
——	3'-azido-3'-deoxythymidin-5'-yl 4-methoxyphenyl α-hydroxy(phenyl)methylphosphonate	1233510-57-0	C₂₄H₂₆N₅O₈P	543.473
——	3'-azido-3'-deoxythymidin-5'-yl phenyl hydroxy(phenyl)methanephosphonate	879688-30-9	C₂₃H₂₄N₅O₇P	513.447
——	3'-azido-3'-deoxythymidin-5'-yl phenyl hydroxy(4-methylphenyl)methanephosphonate	879688-31-0	C₂₄H₂₆N₅O₇P	527.473
——	3'-azido-3'-deoxythymidin-5'-yl phenyl hydroxy(4-chlorophenyl)methanephosphonate	879688-33-2	C₂₃H₂₃ClN₅O₇P	547.892
——	3'-azido-3'-deoxythymidin-5'-yl phenyl hydroxy(4-methoxyphenyl)methanephosphonate	879688-32-1	C₂₄H₂₆N₅O₈P	543.473
——	1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	164652-13-5	C₂₇H₃₀N₁₁O₁₂P	731.575
——	3'-azido-3'-deoxythymidin-5'-yl phenyl hydroxy(4-nitrophenyl)methanephosphonate	879688-34-3	C₂₃H₂₃N₆O₉P	558.444
——	1-Hydroxy-1-(2,4-dinitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	164652-15-7	C₂₇H₂₉N₁₂O₁₄P	776.573
——	1-Hydroxy-1-(2,6-dinitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester	164652-14-6	C₂₇H₂₉N₁₂O₁₄P	776.573
——	1-[(2R,5S)-5-(1-adamantyloxyphosphonoyloxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione	322684-86-6	C₂₀H₂₇N₂O₆P	422.418
司他夫定	stavudin	3056-17-5	C₁₀H₁₂N₂O₄	224.216
——	P-(adamant-1-yl)-2',3'-dideoxyadenosine 5'-hydrogenphosphonate	322684-80-0	C₂₀H₂₈N₅O₄P	433.447

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	O-ethyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate	158689-24-8	C₁₂H₁₈N₅O₆P	359.279
——	3'-azido-2',3'-dideoxythymidine monophosphate	29706-85-2	C₁₀H₁₄N₅O₇P