2,2-bis(1,4-dioxapentl)ethylhydrazine | 1045863-41-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bis(1,4-dioxapentl)ethylhydrazine
• CAS: 1045863-41-9
• 化学式: C₈H₂₀N₂O₄
• 分子量: 208.258
• InChiKey: IFLWOAWHKKQJLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.97
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2,2-bis(1,4-dioxapentl)ethylhydrazine 、 (-)-棉子素 以 二氯甲烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini

  摘要：

  Eight alkyl and six heterocyclic aza-derivatives of gossypol (2-15) have been synthesized using gossypol (1) extracted from Gossypium Herbaceum cottonseeds. The ability of gossypol aza-derivatives to form complexes with NaClO4 has been investigated by electrospray ionisation (ESI) mass spectra recorded in the positive and negative ion detection modes. The gossypol aza-derivatives have been characterized by FT-IR, H-1 and C-13 NMR spectroscopic methods and subsequently tested for their antifungal properties against Fusarium oxysporum. Four alkyl aza-derivatives (2-5), present in the enamine-enamine tautomeric form, have shown activity comparable or higher than that of gossypol against this fungus. To improve the antifungal activity the complexes of the most active compounds 2-5 with NaClO4 were prepared. Complexes of 2 and 5 with NaClO4 have shown antifungal activity higher than that of the uncomplexed compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.051

文献信息

• CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state
  作者：Piotr Przybylski、Wojciech Schilf、Bohdan Kamienski、Bogumil Brzezinski、Franz Bartl

  DOI：10.1002/mrc.2210

  日期：2008.6

  New Schiff bases and new hydrazones were synthesized and studied by 13C and 15N CP/MAS spectroscopy and by 1H1H COSY, 1H13C HMBC, 1H13C HSQC, 1H15N HMQC and 1H15N HSQC correlations. The CP/MAS investigation of gossypol has demonstrated that in the solid state it exists exclusively in the aldehyde‐aldehyde tautomeric form. In contrast, CP/MAS studies of hydrazones and Schiff bases reveal that these

  通过13C和15N CP/MAS光谱以及1H1H COSY、1H13C HMBC、1H13C HSQC、1H15N HMQC和1H15N HSQC相关性合成和研究了新的席夫碱和新的腙。棉酚的 CP/MAS 研究表明，它在固态时仅以醛-醛互变异构形式存在。相比之下，腙和席夫碱的 CP/MAS 研究表明，这些化合物分别以 N-亚胺-N-亚胺和烯胺-烯胺互变异构形式以固态存在。结果表明，C-6、C-7 和 C-11 碳原子的 13C 共振适用于区分固态棉酚氮杂衍生物的互变异构形式。此外，我们已经证明 15N CP/MAS 光谱可用于识别这些互变异构形式。版权所有 © 2008 John Wiley & Sons, Ltd.