N'-(methylsulfonyl)-1-[2-oxo-2-(thiophen-2-yl)ethyl]-1,4,5,6-tetrahydropyridine-3-carbohydrazide | 1254571-56-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N'-(methylsulfonyl)-1-[2-oxo-2-(thiophen-2-yl)ethyl]-1,4,5,6-tetrahydropyridine-3-carbohydrazide
• 英文别名: N'-methylsulfonyl-1-(2-oxo-2-thiophen-2-ylethyl)-3,4-dihydro-2H-pyridine-5-carbohydrazide
• CAS: 1254571-56-6
• 化学式: C₁₃H₁₇N₃O₄S₂
• 分子量: 343.428
• InChiKey: KLOJRDBIORKPKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-{[2-(methylsulfonyl)hydrazinyl]carbonyl}-1-[2-oxo-2-(thiophen-2-yl)ethyl] pyridinium chloride 在 palladium 10% on activated carbon 氢气 、 三乙胺 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、5.0 kPa 条件下， 反应 50.0h， 生成 N'-(methylsulfonyl)-1-[2-oxo-2-(thiophen-2-yl)ethyl]-1,4,5,6-tetrahydropyridine-3-carbohydrazide
  参考文献：
  名称：

  [EN] PIPERIDINE DERIVATIVES USEFUL FOR TREATMENT OF DIEBETES
  [FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES

  摘要：

  公开号：

  WO2010128528A9

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS
  申请人：Dutt Chaitanya

  公开号：US20120046317A1

  公开（公告）日：2012-02-23

  The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.

  本发明涉及一种新的杂环化合物及其药学上可接受的盐，制备该化合物的过程，含有这些化合物的药物组合物以及它们在治疗由于AGEs（高级糖基化终产物）的形成和积累引起的疾病中的应用。本发明的化合物对于治疗由于AGEs的形成和积累引起的糖尿病和衰老相关并发症非常有用，例如神经病变、肾病、小血管病、视网膜病、高血压、心力衰竭、动脉粥样硬化、阿尔茨海默病和皮肤病。
• [EN] NOVEL HETEROCYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2010128528A2

  公开（公告）日：2010-11-11

  The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation endproducts). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.
• [EN] PIPERIDINE DERIVATIVES USEFUL FOR TREATMENT OF DIEBETES<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2010128528A9

  公开（公告）日：2011-03-03