5,8-Dihydro-5-imino-7-amino-8-oxo-carbostyril

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,8-Dihydro-5-imino-7-amino-8-oxo-carbostyril
• 英文别名: 7-amino-5-imino-1H-quinoline-2,8-dione
• 化学式: C₉H₇N₃O₂
• 分子量: 189.173
• InChiKey: ANVZLQYKEGNGGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] TARGETING MB2 OF THE MYC ONCOGENE AND ITS INTERACTION WITH TRRAP IN CANCER<br/>[FR] CIBLAGE DE MB2 DE L'ONCOGÈNE MYC ET SON INTERACTION AVEC TRRAP DANS LE CANCER
  申请人：DARTMOUTH COLLEGE

  公开号：WO2021113347A1

  公开（公告）日：2021-06-10

  Provided are methods and compositions for identifying inhibitors of an interaction between the oncogenic transcription factor MYC and its cofactor TRRAP. The methods involve both cell-based and in vitro approaches for probing an interaction between MYC and TRRAP and for identifying inhibitors of a MYC-TRRAP interaction. Also provided are compounds for use as inhibitors of an interaction between MYC and TRRAP, and methods for developing a cancer therapeutic from such compounds, including methods for derivatizing such inhibitors and for testing the inhibitors and derivatized inhibitors for an ability to treat cancer in a subject. The methods, compounds, and compositions provided herein can provide various advantages, such as a means to target the oncogenic transcription factor MYC in cancer.