1,1,3,3-tetrachloropropanol-2 | 18992-39-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 1,1,3,3-tetrachloropropanol-2
• 英文别名: 1,1,3,3-tetrachloro-propan-2-ol；β.β.β'.β'-Tetrachlor-isopropylalkohol；1,1,3,3-Tetrachlor-propan-2-ol；1,1,3,3-Tetrachlor-isopropylalkohol；1,1,3,3-Tetrachloro-2-propanol；2-Propanol, 1,1,3,3-tetrachloro-；1,1,3,3-tetrachloropropan-2-ol
• CAS: 18992-39-7
• 化学式: C₃H₄Cl₄O
• 分子量: 197.876
• InChiKey: DJQBSIUDOQUMHD-UHFFFAOYSA-N

物化性质

• 熔点：
  34.5-35.5 °C
• 沸点：
  283.97°C (rough estimate)
• 密度：
  1.6120

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1,3,3-tetrachloropropanol-2 在 三氯化磷 作用下， 生成 phosphorochloridous acid bis-(2,2-dichloro-1-dichloromethyl-ethyl) ester
  参考文献：
  名称：

  Dialkyl hydrogen phosphites and dialkyl phosphorochloridites derived from chlorine-substituted alcohols

  摘要：

  DOI：

  10.1007/bf01151360
• 作为产物：
  描述：

  1,1,1,3,3,3-hexachloro-propan-2-ol 在 氢碘酸 作用下， 生成 1,1,3,3-tetrachloropropanol-2
  参考文献：
  名称：

  Neunhoeffer,O.; Spange,A., Justus Liebigs Annalen der Chemie, 1960, vol. 632, p. 22 - 27

  摘要：

  DOI：

文献信息

• New bicyclic compounds as crac channel modulators
  申请人：Almirall, S.A.

  公开号：EP2738172A1

  公开（公告）日：2014-06-04

  The present invention relates to novel compounds which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.

  这项发明涉及一种新型化合物，它们是CRAC通道活性的抑制剂。该发明还涉及含有这些化合物的药物组合物，它们的制备方法以及它们在治疗中的应用。
• NEOPETROSIDES A AND B, AND SYNTHESIS METHOD THEREOF
  申请人：INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20190218206A1

  公开（公告）日：2019-07-18

  The present invention relates to novel pyridine nucleoside compounds, Neopetroside A (NPS A) and Neopetroside B (NPS B) obtained by fractionating an extract of Neopetrosia sp. which is a marine sponge, with ethanol, into n-butanol (n-BuOH). When the NPS A was treated with myocardial cells, it activates oxidative phosphorylation, basal and mitochondrial respiration induced by ATP and ATP synthesis, and stimulates the glycolysis activity and when the NPS A was treated with an ischemic reperfusion injury model, the left ventricular pressure injured by ischemic reperfusion was recovered and the size of myocardial injury site was significantly reduced and as a result, can be provided as the pharmaceutical composition for preventing or treating ischemic heart disease or the health functional food for preventing or improving the same.

  该发明涉及一种新型吡啶核苷化合物，Neopetroside A（NPS A）和Neopetroside B（NPS B），通过将海绵Neopetrosia sp.的提取物用乙醇分级为正丁醇（n-BuOH）而获得。当NPS A与心肌细胞接触时，它会激活由ATP诱导的氧化磷酸化、基础和线粒体呼吸以及ATP合成，并刺激糖酵解活性；当NPS A与缺血再灌注损伤模型接触时，通过缺血再灌注损伤恢复左心室压力，明显减小心肌损伤部位的大小，因此可以作为预防或治疗缺血性心脏病的药物组合或预防或改善相同疾病的保健功能食品。
• 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
  申请人：——

  公开号：US20030078428A1

  公开（公告）日：2003-04-24

  Phenylamino benzhydroxamic acid derivatives of formula (I) where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and where R 7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.

  苯胺基苯基羟羟肟酸衍生物的化学式（I），其中R1、R2、R3、R4、R5和R6为氢或取代基，如烷基，R7为氢或有机基团，是MEK的有效抑制剂，因此在治疗癌症和其他增殖性疾病（如牛皮癣和再狭窄）方面具有良好效果。
• [EN] 1,2,3,6-TETRAHYDROAZEPINO[4,5-B]INDOLE-5-CARBOXYLATE NUCLEAR RECEPTOR INHIBITORS<br/>[FR] INHIBITEURS DES RÉCEPTEURS NUCLÉAIRES DE 1,2,3,6-TÉTRAHYDROAZÉPINO[4,5-B]INDOLE-5-CARBOXYLATE
  申请人：WYETH CORP

  公开号：WO2010036362A1

  公开（公告）日：2010-04-01

  Provided are certain 1,2,3,6- tetrahydroazepino[4,5-b]indole-5-carboxylate compounds which are useful for modulating the activity of nuclear receptors, such as farnesoid X receptors, and/or for the treatment, prevention, or amelioration diseases or disorders related to the activity of these receptors.

  提供了一些1,2,3,6-四氢噁二氮杂并[4,5-b]吲哚-5-羧酸酯化合物，这些化合物对调节核受体的活性（如法尼索X受体）非常有用，或者用于治疗、预防或改善与这些受体活性相关的疾病或疾病。
• [EN] 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS<br/>[FR] DERIVES D'ACIDE BENZHYDROXAMIQUE PHENYLAMINO 4-BROMO OU 4-IODO ET UTILISATION DE CES DERNIERS EN TANT QU'INHIBITEURS DE MEK
  申请人：WARNER-LAMBERT COMPANY

  公开号：WO1999001426A1

  公开（公告）日：1999-01-14

  (EN) Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.(FR) On décrit des dérivés d'acide benzhydroxamique phénylamino de formule (I). Dans la formule R1, R2, R3, R4, R5 et R6 représentent hydrogène ou des groupes substituants tels que alkyle; R7 représentant hydrogène ou un radical organique. Ces dérivés sont de puissants inhibiteurs de MEK et en tant que tels ils sont efficaces dans le traitement du cancer et d'autres maladies proliférantes telles que le psoriasis et la resténose.

  Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis. 翻译：公式（I）中的苯氨基苯甲酰羟肟酸衍生物，其中R1、R2、R3、R4、R5和R6是氢或取代基，例如烷基，而R7是氢或有机基团，是MEK的强效抑制剂，因此在治疗癌症和其他增生性疾病，如银屑病和再狭窄方面非常有效。

表征谱图