6-[3-({2-[(2-carboxyethyl)oxy]ethyl}oxy)propyl]-4-oxo-1-propyl-1,4-dihydro-3-quinolinecarboxylic acid | 1253591-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[3-({2-[(2-carboxyethyl)oxy]ethyl}oxy)propyl]-4-oxo-1-propyl-1,4-dihydro-3-quinolinecarboxylic acid
• 英文别名: 6-(3-[2-(2-carboxy-ethoxy)-ethoxy]-propyl)-4-oxo-1-propyl-1,4-dihydro-quinoline-3-carboxylic acid；6-[3-[2-(2-Carboxyethoxy)ethoxy]propyl]-4-oxo-1-propylquinoline-3-carboxylic acid
• CAS: 1253591-47-7
• 化学式: C₂₁H₂₇NO₇
• 分子量: 405.448
• InChiKey: GEKFPKPTPOBNMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-[3-({2-[(2-carboxyethyl)oxy]ethyl}oxy)propyl]-4-oxo-1-propyl-1,4-dihydro-3-quinolinecarboxylic acid 、 2'-O-acetylazithromycin 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

  摘要：

  The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.050
• 作为产物：
  描述：

  6-[3-({2-[(2-cyanoethyl)oxy]ethyl}oxy)propyl]-4-oxo-1-propyl-1,4-dihydro-3-quinolinecarboxylic acid 在 硫酸 、 水 作用下， 反应 19.0h， 以0.74 g的产率得到6-[3-({2-[(2-carboxyethyl)oxy]ethyl}oxy)propyl]-4-oxo-1-propyl-1,4-dihydro-3-quinolinecarboxylic acid
  参考文献：
  名称：

  Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

  摘要：

  The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.050

文献信息

• [EN] ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS<br/>[FR] MACROLIDES A LIAISON ESTER UTILES POUR LE TRAITEMENT D'INFECTION MICROBIENNES
  申请人：PLIVA ISTRAZIVACKI INST D O O

  公开号：WO2005108412A1

  公开（公告）日：2005-11-17

  The present invention relates to 14- or 15-membered macrolides substituted at the 4” position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infoections in a human or animal body.

  本发明涉及在式（I）的4”位置被取代的14-或15-环大环内酯及其药学上可接受的衍生物，以及它们的制备方法和在人体或动物体内治疗或预防全身或局部微生物感染中的用途。
• Ester Linked Macrolides Useful For The Treatment of Microbial Infections
  申请人：Alihodzic Sulejman

  公开号：US20080255060A1

  公开（公告）日：2008-10-16

  The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

  本发明涉及在式(I)的4"位置取代的14或15元大环内酯及其药学上可接受的衍生物，以及它们的制备方法和在人或动物体内治疗或预防系统性或局部微生物感染的用途。
• ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1756135B1

  公开（公告）日：2009-08-12
• Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit
  作者：Maja Matanović Škugor、Vlado Štimac、Ivana Palej、Đurdjica Lugarić、Hana Čipčić Paljetak、Darko Filić、Marina Modrić、Ivica Đilović、Dubravka Gembarovski、Stjepan Mutak、Vesna Eraković Haber、David J. Holmes、Zrinka Ivezić-Schoenfeld、Sulejman Alihodžić

  DOI：10.1016/j.bmc.2010.06.050

  日期：2010.9

  The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported. (C) 2010 Elsevier Ltd. All rights reserved.