N-acetyl-D,L-aminoadipic acid | 66428-29-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-D,L-aminoadipic acid
• 英文别名: N-acetyl-L-2-aminoadipate；2-acetamidohexanedioic acid
• CAS: 66428-29-3
• 化学式: C₈H₁₃NO₅
• 分子量: 203.195
• InChiKey: FTTGAAZKBNZDCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-acetyl-D,L-aminoadipic acid 在 ammonium hydroxide 、 重水 、 乙酸酐 、 碳酸氢钠 、 sodium carbonate 、 二环己胺 作用下， 以 乙醚 、 水 为溶剂， 反应 105.0h， 生成 N-(benzyloxycarbonyl)<α-2H>aminoadipic acid methyl ester
  参考文献：
  名称：

  Synthesis of an isotopically labeled dilactam-bridged tetrapeptide

  摘要：

  DOI：

  10.1021/jo00233a007
• 作为产物：
  描述：

  DL-a-氨基己二酸 、 乙酸酐 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 24.0h， 以78%的产率得到N-acetyl-D,L-aminoadipic acid
  参考文献：
  名称：

  Synthesis of an isotopically labeled dilactam-bridged tetrapeptide

  摘要：

  DOI：

  10.1021/jo00233a007

文献信息

• Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with pathogenic microbes
  申请人：DermBiont, Inc.

  公开号：US11040077B2

  公开（公告）日：2021-06-22

  Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.

  本文公开了使用源自人类的 Lividum Janthinobacterium 的组合物和方法。组合物可改善皮肤健康。方法可包括在宿主或宿主区域（如皮肤或粘膜）上施用源于人的生发的Lividum Janthinobacterium，以最大限度地减少一种或多种微生物的存在，最大限度地提高治疗效果，和/或改善健康状况。减少病原微生物的方法可包括向表面施用一种组合物，该组合物包括来源于人类的Janthinobacterium lividum和一种可接受的载体。组合物和方法可包括益生元，以最大限度地提高生长和/或代谢物。组合物和方法可包括来源于人的猪蓝细菌代谢物，如violacein、prodigiosin、吲哚-3-甲醛、兰特益生菌和/或其他后益生菌。
• MANESIS, NICK J.;GOODMAN, MURRAY, J. ORG. CHEM., 52,(1987) N 24, 5342-5349
  作者：MANESIS, NICK J.、GOODMAN, MURRAY

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS FOR IMPROVING SKIN HEALTH AND FOR THE TREATMENT AND PREVENTION OF DISEASES, DISORDERS AND CONDITIONS ASSOCIATED WITH PATHOGENIC MICROBES
  申请人：DermBiont, Inc.

  公开号：US20200345799A1

  公开（公告）日：2020-11-05

  Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum . Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.
• Synthesis of an isotopically labeled dilactam-bridged tetrapeptide
  作者：Nick J. Manesis、Murray Goodman

  DOI：10.1021/jo00233a007

  日期：1987.11