galanthine | 517-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: galanthine
• 英文别名: (1S,14S,15S,16S)-4,5,14-trimethoxy-9-azatetracyclo[7.6.1.02,7.012,16]hexadeca-2,4,6,12-tetraen-15-ol
• CAS: 517-78-2
• 化学式: C₁₈H₂₃NO₄
• 分子量: 317.385
• InChiKey: VOIMPDXOQJYVDI-WNRNVDISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  galanthine 280.0 ℃ 、399.97 Pa 条件下， 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Alkaloids of the Amaryllidaceae. IX. On the Structure of Galanthine¹

  摘要：

  DOI：

  10.1021/ja01597a079

文献信息

• Natural compounds and fibrosis
  申请人：MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)

  公开号：US11185539B2

  公开（公告）日：2021-11-30

  The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.

  本发明涉及一种用于预防或治疗纤维化方法的 miR-671-5p 抑制剂。此外，本发明还包括一种包含所述 miR-671-5p 抑制剂的试剂盒。本发明还涉及一种用于鉴定预防或治疗纤维化的化合物的体外方法。
• Interconversions of Amaryllidaceae Alkaloids by Sodium and Amyl Alcohol¹
  作者：H. M. Fales、W. C. Wildman

  DOI：10.1021/ja01549a073

  日期：1958.8
• EXTRACT OF HIPPEASTRUM PAPILIO RICH IN GALANTHAMINE
  申请人：Berbee Beheer BV

  公开号：EP2999480A1

  公开（公告）日：2016-03-30
• Composition of extracts from the genus Hippeastrum and the use of their components for the production of pharmaceuticals and dietary supplements
  申请人：BERBEE BEHEER BV.

  公开号：US20170182111A1

  公开（公告）日：2017-06-29

  A composition of extracts from the genus Hippeastrum and their components is intended for the production of pharmaceuticals and dietary supplements. The composition consists of galanthamine from 40% to 98%, haemanthamine from 0.01% to 35%, narwedine from 0.01% to 10%, and/or other alkaloids of homolycorine-, and/or tazettine-, and/or monthanine- and/or haemanthamine- and/or galanthamine- and/or lycorine-type from 0.001% to 35%, and non-alkaloid plant metabolites from 0.001 to 1%, derived from the total extract of the genus Hippeastrum . The alkaloid content can vary from 0.01% to 99% and non-alkaloid plant metabolites and/or other inactive excipients and/or solvents from 1% to 99.9%, respectively. The composition may be in dry or liquid form. It is used to isolate pure compounds of haemanthamine and galanthamine.
• NATURAL COMPOUNDS AND FIBROSIS
  申请人：MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)

  公开号：US20190350923A1

  公开（公告）日：2019-11-21

  The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.