10-methyl-6-dodecanolide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 10-methyl-6-dodecanolide
• 英文别名: 7-(4-Methylhexyl)oxepan-2-one；7-(4-methylhexyl)oxepan-2-one
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: FWCJVEHVQQNKBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-methylhexyl)cyclohexanone 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以87%的产率得到10-methyl-6-dodecanolide
  参考文献：
  名称：

  Novel Caprolactones from a Marine Streptomycete

  摘要：

  Two new caprolactones, (R)-10-methyl-6-undecanolide (1) and (6R,10S)-10-methyl-6-dodecanolide (2), were identified in the lipid extract of a marine streptomycete (isolate B6007). Their structures were proposed on the basis of GC-MS experiments and proved by synthesis. The absolute configuration of the compounds was established by comparison of the natural and synthetic stereoisomers using chiral gas chromatography. These caprolactones show a moderate phytotoxicity and a promising activity against cancer cells with concomitant low general cytotoxicity.

  DOI：

  10.1021/np030321z

文献信息

• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：enEvolv, Inc.

  公开号：EP3027754A1

  公开（公告）日：2016-06-08
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17
• [EN] PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING<br/>[FR] PROCÉDÉS ET CELLULES HÔTES POUR INGÉNIERIE BIOMOLÉCULAIRE, GÉNOMIQUE ET DE LA VOIE
  申请人：ENEVOLV INC

  公开号：WO2015017866A1

  公开（公告）日：2015-02-05

  The present disclosure provides compositions and methods for genomic engineering.
• Novel Caprolactones from a Marine Streptomycete
  作者：Katja Stritzke、Stefan Schulz、Hartmut Laatsch、Elisabeth Helmke、Winfried Beil

  DOI：10.1021/np030321z

  日期：2004.3.1

  Two new caprolactones, (R)-10-methyl-6-undecanolide (1) and (6R,10S)-10-methyl-6-dodecanolide (2), were identified in the lipid extract of a marine streptomycete (isolate B6007). Their structures were proposed on the basis of GC-MS experiments and proved by synthesis. The absolute configuration of the compounds was established by comparison of the natural and synthetic stereoisomers using chiral gas chromatography. These caprolactones show a moderate phytotoxicity and a promising activity against cancer cells with concomitant low general cytotoxicity.