Scolopendrine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Scolopendrine
• 英文别名: [7-[(4-hydroxy-3-methoxyphenyl)methyl]-3-methoxy-2-oxo-1H-quinolin-8-yl] hydrogen sulfate
• 化学式: C₁₈H₁₇NO₈S
• 分子量: 407.4
• InChiKey: GAQLINTXWPLDAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Novel Quinoline Compound, and Composition Containing Centipede Extract or Compounds Isolated Therefrom for Prevention and Treatment of Cardiovascular Disease
  申请人：Park Ho Yong

  公开号：US20090247758A1

  公开（公告）日：2009-10-01

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
• NOVEL QUINOLINE COMPOUND, AND COMPOSITION CONTAINING CENTIPEDE EXTRACT OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：PARK Ho Yong

  公开号：US20120220626A1

  公开（公告）日：2012-08-30

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
• US8212042B2
  申请人：——

  公开号：US8212042B2

  公开（公告）日：2012-07-03
• US8362034B2
  申请人：——

  公开号：US8362034B2

  公开（公告）日：2013-01-29
• [EN] NOVEL QUINOLINE COMPOUND, AND COMPOSITION CONTAINING CENTIPEDE EXTRACT OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE<br/>[FR] NOUVEAU COMPOSE DE QUINOLEINE, ET COMPOSITION CONTENANT UN EXTRAIT DE CENTIPEDE OU DES COMPOSES ISOLES DE CELUI-CI AFIN DE PREVENIR ET TRAITER DES MALADIES CARDIOVASCULAIRES
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2007073021A1

  公开（公告）日：2007-06-28

  [EN] The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
  [FR] L'invention concerne une composition destinée à prévenir et à traiter des maladies cardiovasculaires contenant un nouveau composé de quinoléine, des extraits de centipède ou des composés isolés de ces extraits. Le nouveau composé de quinoléine, les extraits de centipède ou un composé de quinoléine et un composé phénolé isolé des extraits de l'invention présentent une activité antioxydante du LDL, une activité inhibitrice ACAT, et des activités anti-inflammatoires excellentes, de manière à pouvoir être introduites en tant que principe actif dans une composition destinée à prévenir et à traiter des maladies cardiovasculaires telles que l'hyperlipidémie, l'athérosclérose, les maladies coronariennes, et l'infarctus du myocarde induit par l'oxydation de LDL, la synthèse, l'accumulation et l'inflammation d'ester de cholestéryle.