2,8-Dihydroxy-3,4-dimethoxyquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,8-Dihydroxy-3,4-dimethoxyquinoline
• 英文别名: 8-hydroxy-3,4-dimethoxy-1H-quinolin-2-one
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.21
• InChiKey: GGHDZCVRYSXWSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2124560A1

  公开（公告）日：2009-12-02
• Novel Quinoline Compound, and Composition Containing Centipede Extract or Compounds Isolated Therefrom for Prevention and Treatment of Cardiovascular Disease
  申请人：Park Ho Yong

  公开号：US20090247758A1

  公开（公告）日：2009-10-01

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
• NOVEL QUINOLINE COMPOUND, AND COMPOSITION CONTAINING CENTIPEDE EXTRACT OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：PARK Ho Yong

  公开号：US20120220626A1

  公开（公告）日：2012-08-30

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
• US8212042B2
  申请人：——

  公开号：US8212042B2

  公开（公告）日：2012-07-03
• US8362034B2
  申请人：——

  公开号：US8362034B2

  公开（公告）日：2013-01-29