5,7-Dibutoxy-2-phenyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7-Dibutoxy-2-phenyl-chromen-4-one
• 英文别名: 5,7-dibutoxy-2-phenyl-4H-chromen-4-one；5,7-dibutoxy-2-phenylchromen-4-one
• 化学式: C₂₃H₂₆O₄
• mdl: MFCD00707895
• 分子量: 366.457
• InChiKey: HGFDSLZROUUCKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  白杨素 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 以41%的产率得到7-丁氧基-5-羟基-2-苯基色烯-4-酮
  参考文献：
  名称：

  Synthesis and hypoglycemic effect of chrysin derivatives

  摘要：

  A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00092-x

文献信息

• Synthesis and hypoglycemic effect of chrysin derivatives
  作者：Joon-Su Shin、Kyoung-Soon Kim、Myoung-Bohm Kim、Jae-Hoon Jeong、Bak-Kwang Kim

  DOI：10.1016/s0960-894x(99)00092-x

  日期：1999.3

  A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect. (C) 1999 Elsevier Science Ltd. All rights reserved.