Phenylacetothiohydroxamic Acid | 10593-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenylacetothiohydroxamic Acid
• 英文别名: Phenylacetothiohydroxamsaeure；Phenylthioacetohydroximic acid；N-hydroxy-2-phenylethanethioamide
• CAS: 10593-79-0
• 化学式: C₈H₉NOS
• 分子量: 167.232
• InChiKey: IHTJGIKQNHDTSX-UHFFFAOYSA-N

物化性质

• 熔点：
  73-74.2 °C
• 沸点：
  310.3±35.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Phenylacetothiohydroxamic Acid 、 sodium,[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphoryl] phosphate 在 DL-dithiothreitol 、 calf intestine alkaline phosphatase 、 UDP-glycosyltransferase 74B₁ from Arabidopsis thaliana 作用下， 以 aq. phosphate buffer 、 二甲基亚砜 为溶剂， 反应 2.0h， 以69%的产率得到benzyl desulphoglucosinolate
  参考文献：
  名称：

  来自拟南芥的UGT74B1作为通用的生物催化剂，用于合成硫代硫代葡萄糖苷†

  摘要：

  硫糖苷，即使在自然界中很少见，也因其生物学特性而受到越来越多的关注。这类化合物的化学合成已被广泛研究，但有关其生物合成的报道却很少。在此，我们结合酶学，生物有机化学和分子建模等不同领域的实验，希望证明葡糖基转移酶UGT74B1的多功能性及其合成能力，可用于制备多种天然和非天然的脱硫糖基磺酸盐。

  DOI：

  10.1039/c6ob01003b
• 作为产物：
  描述：

  苯乙醛 在 吡啶 、 N-氯代丁二酰亚胺 、 sodiumsulfide nonahydrate 、 盐酸羟胺 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.5h， 生成 Phenylacetothiohydroxamic Acid
  参考文献：
  名称：

  来自拟南芥的UGT74B1作为通用的生物催化剂，用于合成硫代硫代葡萄糖苷†

  摘要：

  硫糖苷，即使在自然界中很少见，也因其生物学特性而受到越来越多的关注。这类化合物的化学合成已被广泛研究，但有关其生物合成的报道却很少。在此，我们结合酶学，生物有机化学和分子建模等不同领域的实验，希望证明葡糖基转移酶UGT74B1的多功能性及其合成能力，可用于制备多种天然和非天然的脱硫糖基磺酸盐。

  DOI：

  10.1039/c6ob01003b

文献信息

• Biosynthetic Engineering of Glucosinolates
  申请人：Geu-Flores Fernando

  公开号：US20110016582A1

  公开（公告）日：2011-01-20

  The invention provides methods and materials, such as newly characterised genes, and novel processes, for converting a host from a phenotype whereby the host is unable to carry out glucosinolate (GSL) biosynthesis or chain elongation from an amino acid GSL-precursor to a phenotype whereby the host carries out said biosynthesis or elongation.

  本发明提供了一种将宿主从无法进行葡萄糖硫酸盐（GSL）生物合成或链延伸的表型转化为能够进行上述生物合成或延伸的表型的方法和材料，例如新鉴定的基因和新型工艺。
• Plants with reduced glucosinolate content
  申请人：PLANT GENETIC SYSTEMS N.V.

  公开号：EP0771878A1

  公开（公告）日：1997-05-07

  The present invention relates to a method to reduce glucosinolate production and/or accumulation in plants wherein a reduced glucosinolate content is desired, particularly in the seeds of these plants. In accordance with the present invention, chimeric gene constructs inhibiting an enzyme responsible for glucosinolate production, the enzyme UDP-glucose:thiohydroximate S-glucosyltransferase (further referred to as "S-GT") are provided. Further in accordance with the present invention, plants are provided having substantially lower glucosinolate levels in their tissues, particularly in their seeds, which permit a significant expansion of the germplasm basis for the breeding of new oilseed rape varieties having lower glucosinolate levels, particularly in their seeds.

  本发明涉及一种减少植物中葡萄糖苷酸的产生和/或积累的方法，在这种植物中，特别是在这些植物的种子中，需要减少葡萄糖苷酸的含量。根据本发明，提供了抑制负责葡萄糖苷酸生产的酶 UDP-葡萄糖：硫代羟基 S-葡萄糖基转移酶（进一步称为 "S-GT"）的嵌合基因构建体。此外，根据本发明，所提供的植物在其组织中，特别是在其种子中的葡萄糖苷酸含量大大降低，这使得培育具有较低葡萄糖苷酸含量，特别是种子中葡萄糖苷酸含量较低的油菜新品种的种质基础得以显著扩大。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• Counterattack reagents: Thiosilanes in the conversion of nitro compounds to thiohydroxamic acids and thiohydroximates
  作者：Jih Ru Hwu、Shwu-Chen Tsay

  DOI：10.1016/s0040-4020(01)89057-8

  日期：——