Isovalerylcarnitine | 31023-24-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Isovalerylcarnitine
• 英文别名: 3-(3-methylbutanoyloxy)-4-(trimethylazaniumyl)butanoate
• CAS: 31023-24-2
• 化学式: C12H23NO4
• 分子量: 245.32
• InChiKey: IGQBPDJNUXPEMT-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 储存条件：
  2-8°C

制备方法与用途

生物活性

Isovalerylcarnitine 是 L-亮氨酸分解代谢的产物，能够增加钙蛋白酶的活性。

靶点

Human 内源性代谢物

文献信息

• METHODS FOR USING AND BIOMARKERS FOR AMPK-ACTIVATING COMPOUNDS
  申请人：Hitoshi Yasumichi

  公开号：US20150087673A1

  公开（公告）日：2015-03-26

  Disclosed are methods of using AMPK-activating compounds, for example, in the treatment of cancer and disorders of vascular flow. Also disclosed are biomarkers for AMPK and uses thereof, for example, in the diagnosis and treatment of AMPK-linked disorders. In certain embodiments, the AMPK-activating compounds have the structural formula wherein E, J, T, D 1 , D 2 , D 3 , the ring system denoted by “B”, T, R 3 , R 4 , w and x are as described herein.

  本文公开了使用AMPK激活化合物的方法，例如在癌症和血管流动障碍的治疗中的应用。还公开了AMPK的生物标志物及其用途，例如在AMPK相关疾病的诊断和治疗中的应用。在某些实施例中，AMPK激活化合物具有以下结构式，其中E、J、T、D1、D2、D3、由“B”表示的环系统、T、R3、R4、w和x如本文所述。
• METHODS OF TREATING DISEASES AND DISORDERS RESULTING FROM BETA CORONAVIRUS INFECTION
  申请人：T3D Therapeutics, Inc.

  公开号：US20210369680A1

  公开（公告）日：2021-12-02

  This disclosure describes the use of indane acetic acid derivatives which are PPAR agonists, including PPAR delta, PPAR gamma, and dual PPAR delta and gamma agonists, and which penetrate the blood brain barrier to achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of betacoronavirus diseases, such as COVID-19 and COVID-19 related co-morbid diseases, including Acute Respiratory Distress and CNS disorders, such as delirium and cognitive impairment.

  本公开说明了使用indane乙酸衍生物作为PPAR激动剂，包括PPAR delta，PPAR gamma和双重PPAR delta和gamma激动剂，这些激动剂穿过血脑屏障，在非毒性剂量下实现有效的脑血浆药物水平，用于治疗β冠状病毒疾病，如COVID-19和COVID-19相关的共病疾病，包括急性呼吸窘迫和中枢神经系统疾病，如谵妄和认知障碍。
• Process for the production of fine chemicals
  申请人：Puzio Piotr

  公开号：US20070118916A1

  公开（公告）日：2007-05-24

  The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof, preferably in plastids. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.

  本发明涉及一种在微生物、植物细胞、植物、植物组织或其一部分中生产精细化学品的过程，优选在质体中进行。此外，本发明还涉及核酸分子、多肽、核酸构建物、载体、抗体、宿主细胞、植物组织、繁殖材料、收获材料、植物、微生物以及农业组合物以及它们的用途。
• A pharmaceutical preparation comprising an acylcarnitine
  申请人：Kuratsune, Hirohiko

  公开号：EP0681839A2

  公开（公告）日：1995-11-15

  A pharmaceutical preparation comprising an acylcarnitine or a pharmacologically acceptable salt thereof is administered orally or parenterally to treat or prevent a symptom caused by acylcarnitine metabolic dysfunction. The acylcarnitine may be acetylcarnitine, propionylcarnitine, butyrylcarnitine, isobutyrylcarnitine, valerylcarnitine, isovalerylcarnitine, hexanoylcarnitine and so on.

  口服或肠外给药包含酰基肉碱或其药理学上可接受的盐的药物制剂，用于治疗或预防酰基肉碱代谢功能障碍引起的症状。酰基肉碱可以是乙酰肉碱、丙酰肉碱、丁酰肉碱、异丁酰肉碱、戊酰肉碱、异戊酰肉碱、己酰肉碱等。
• Labelled acyl-L-carnitine and diagnostic agent
  申请人：Japan Science and Technology Corporation

  公开号：EP0770400A2

  公开（公告）日：1997-05-02

  The present invention provides a labelled acyl-L-carnitine, which is an acyl-L-carnitine, a salt thereof or a derivative thereof, of which carbon group is labelled with a radionuclide or a stable isotope. It is possible to diagnose human diseases falling under acyl-carnitine metabolic syndrome, or human diseases due to structural/functional disorder of the brain by measuring the behavior of the labelled acyl-L-carnitine in various tissues or a biological sample from a subject administered with one or more kinds of the labelled acyl-L-carnitines.

  本发明提供了一种标记的酰基-L-肉碱，它是一种酰基-L-肉碱、其盐或其衍生物，其碳基被放射性核素或稳定同位素标记。通过测量被标记的酰基-L-肉碱在各种组织或生物样本中的表现，可以诊断属于酰基-L-肉碱代谢综合征的人类疾病，或由于大脑结构/功能紊乱引起的人类疾病。