theaflavin | 189354-66-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: theaflavin
• 英文别名: 3,4,6-trihydroxy-1,8-bis-(3,5,7-trihydroxy-chroman-2-yl)-benzocyclohepten-5-one；3,4,5-trihydroxy-1,8-bis(3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl)benzo[7]annulen-6-one；3,4,6-trihydroxy-1,8-bis(3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl)benzo[7]annulen-5-one
• CAS: 189354-66-3
• 化学式: C₂₉H₂₄O₁₂
• 分子量: 564.502
• InChiKey: IPMYMEWFZKHGAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  41
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  218
• 氢给体数：
  9
• 氢受体数：
  12

文献信息

• Solid state matrix, process of preparation thereof, and process of preparation of theaflavins
  申请人：Singh Harsh Pratap

  公开号：US10131727B2

  公开（公告）日：2018-11-20

  The present invention relates to a process for the development of a highly efficient solid state matrix by the activation of acrylate based polymer resin having specialized functional groups with 1,1-Carboxyl diimidazole for immobilizing biologically active macromeloecules such as oxidases, in particular plant oxidases and the most preferred being tea polyphenol oxidase through indirect covalent bonding/cross linking on such activated polymer resin support, are thermally stable, gives very high number of turnovers in vitro (“n” times) with tea substrate forming exclusive product Theaflavins without any loss of biological activity and leaving the product remaining in vitro with adherence to matrix rendering the matrix safe towards product poisoning and subsequent partial or complete loss of biological activity of the matrix bound enzyme system and thus well adapted to and well suited biorectors based on such systems. It is unique with respect to its recyclability or otherwise uneconimical tea substrates such as seed and flower substrates into theaflavins both with respect to crude substrate or purified ones.

  本发明涉及一种高效固态基质的开发过程，其方法是用 1,1-羧基二咪唑活化具有特 殊官能团的丙烯酸酯基聚合物树脂，通过间接共价键合/交联将生物活性大分子如氧化 酶固定在这种活化的聚合物树脂载体上，特别是植物氧化酶，最优选的是茶多酚氧化酶、热稳定性高，在体外与茶叶底物形成专有产物茶黄素的翻转次数极高（"n "次），且不会丧失任何生物活性，并使产物留在体外，附着在基质上，使基质不会受到产物中毒的影响，也不会随后部分或完全丧失与基质结合的酶系统的生物活性，因此非常适合基于此类系统的生物抑制剂。无论是粗底物还是纯底物，它都具有独特的可回收性，可将种子和花朵等非同源茶底物转化为茶黄素。
• Solid State Matrix, Process of Preparation Thereof, and Process of Preparation of Theaflavins
  申请人：Singh Harsh Pratap

  公开号：US20090298140A1

  公开（公告）日：2009-12-03

  The present invention relates to a process for the development of a highly efficient solid state matrix by the activation of acrylate based polymer resin having specialized functional groups with 1,1-Carboxyl diimidazole for immobilizing biologically active macromeloecules such as oxidases, in particular plant oxidases and the most preferred being tea polyphenol oxidase through indirect covalent bonding/cross linking on such activated polymer resin support, are thermally stable, gives very high number of turnovers in vitro (“n” times) with tea substrate forming exclusive product Theaflavins without any loss of biological activity and leaving the product remaining in vitro with adherence to matrix rendering the matrix safe towards product poisoning and subsequent partial or complete loss of biological activity of the matrix bound enzyme system and thus well adapted to and well suited biorectors based on such systems. It is unique with respect to its recyclability or otherwise uneconimical tea substrates such as seed and flower substrates into theaflavins both with respect to crude substrate or purified ones.