Tricin 7-O-glucoside | 32769-01-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Tricin 7-O-glucoside
• 英文别名: 5-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• CAS: 32769-01-0
• 化学式: C₂₃H₂₄O₁₂
• 分子量: 492.4
• InChiKey: JGXFMIJHKASCIZ-UHFFFAOYSA-N

物化性质

• 熔点：
  244-246 °C
• 沸点：
  819.2±65.0 °C(Predicted)
• 密度：
  1.582±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  185
• 氢给体数：
  6
• 氢受体数：
  12

制备方法与用途

Tricin 7-O-β-D-吡喃葡萄糖苷是一种强效口服神经保护剂，能够诱导细胞凋亡，并通过降低TNF-α诱导的荧光素-κB-α、荧光素NF-κB和HMGB1的表达来发挥其作用。

文献信息

• TRICIN DERIVATIVES AND COMPOSITIONS THEREOF FOR CANCER TREATMENT
  申请人：GIDEKEL MANUEL

  公开号：US20200261486A1

  公开（公告）日：2020-08-20

  Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-β-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-β-D-glucopyranoside derivatives. Tricin 7-O-β-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-β-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.

  提供了治疗癌症和采用T细胞治疗（ACT）的组合物和方法。该组合物包括一种或多种三香素7-O-β-D-葡萄糖苷（ANTARTINA®）的衍生物。该组合物包括一种或多种药用可接受的辅料，方便输送三香素7-O-β-D-葡萄糖苷衍生物。此处描述的三香素7-O-β-D-葡萄糖苷衍生物包括乙酰化三香素7-O-β-D-葡萄糖苷以及葡萄糖、麦芽糖、纤维二糖、乳糖、木糖和半乳糖衍生物。该方法包括治疗或减少患结肠癌和肝细胞癌的风险。
• Tricin derivatives and compositions thereof for cancer treatment
  申请人：NEOCAGE SL

  公开号：US11534449B2

  公开（公告）日：2022-12-27

  Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-β-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-β-D-glucopyranoside derivatives. Tricin 7-O-β-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-β-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.

  本文提供了用于治疗癌症和采用性 T 细胞疗法 (ACT) 的组合物和方法。这些组合物包括一种或多种三尖杉素 7-O-β-D-吡喃葡萄糖苷（ANTARTINA®）的衍生物。组合物包含一种或多种药学上可接受的赋形剂，便于三尖杉素 7-O-β-D-Glucopyranoside 衍生物的给药。本文所述的三尖杉素 7-O-β-D-吡喃葡萄糖苷衍生物包括乙酰化三尖杉素 7-O-β-D-吡喃葡萄糖苷，以及葡萄糖、麦芽糖、纤维生物糖、乳糖、木糖和半乳糖衍生物。这些方法包括治疗结肠直肠癌和肝细胞癌或降低其患病风险。
• METHOD FOR PREPARING ENZYME-TREATED ZIZANIA LATIFOLIA TURCZ. EXTRACT HAVING INCREASED TRICIN CONTENT, AND COMPOSITION FOR WHITENING, WRINKLE REDUCTION, ANTI-INFLAMMATION, ANTI-ALLERGY AND MOISTURIZATION, PREPARED THEREBY
  申请人：BTC CORPORATION

  公开号：US20210251883A1

  公开（公告）日：2021-08-19

  The present invention relates to a method of preparing an enzyme-treated Zizania latifolia Turcz. extract and a composition prepared therefrom, and the enzyme-treated Zizania latifolia Turcz. extract prepared by the above method contains a high content of tricin, and thus it can be usefully used as a cosmetic composition or a health functional food composition for whitening, wrinkle improvement, anti-inflammatory, anti-allergy and moisturizing.