artonin Y

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: artonin Y
• 英文别名: 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromen-4-one
• 化学式: C₂₀H₁₈O₆
• 分子量: 354.359
• InChiKey: KIZVKNPTBJVGLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  artonin Y 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以3.5 mg的产率得到dihydroartonin Y
  参考文献：
  名称：

  单侧 Wessely-Moser 重排反应的机理

  摘要：

  DOI：

  10.3987/com-99-8827
• 作为产物：
  描述：

  在 盐酸 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 生成 artonin Y
  参考文献：
  名称：

  Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents

  摘要：

  A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.120

文献信息

• Mechanism on One-sided Wessely-Moser Rearrangement Reaction
  作者：Taro Nomura、Kazuki Shinomiya、Yoshio Hano

  DOI：10.3987/com-99-8827

  日期：——
• Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents
  作者：Xiaowu Dong、Lingling Qi、Chaoyi Jiang、Jing Chen、Erqing Wei、Yongzhou Hu

  DOI：10.1016/j.bmcl.2009.04.120

  日期：2009.6

  A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects. (C) 2009 Elsevier Ltd. All rights reserved.