3-hydroxy-10,13-dimethyl-2,3,4,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17-dione | 566-19-8

• 物质功能分类: 天然产物 - 甾体化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-hydroxy-10,13-dimethyl-2,3,4,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17-dione
• CAS: 566-19-8
• 化学式: C₁₉H₂₆O₃
• 分子量: 302.414
• InChiKey: KPRGOTLNGIBVFL-UHFFFAOYSA-N

物化性质

• 熔点：
  245-248 °C
• 沸点：
  477.1±45.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)
• 溶解度：
  DMF：25mg/mL； DMF:PBS(pH 7.2)(1:1)：0.5 mg/ml； DMSO：15mg/mL；乙醇：10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2937290090
• 储存条件：
  | 室温 |

SDS

---

Section 1. Chemical Product and Company Identification
Dehydroepiandrosterone, 7-Keto
Common Name/
Trade Name
Dehydroepiandrosterone, 7-Keto

---

Section 4. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Not available.
Serious Ingestion

---

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards in
Risks of explosion of the product in presence of static discharge: Not available.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated
Special Remarks on
temperatures
Fire Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Special Remarks on
explosion hazard.
Explosion Hazards

---

Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
Small Spill
water on the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
Large Spill
the contaminated surface and allow to evacuate through the sanitary system.
Dehydroepiandrosterone, 7-Keto

---

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
breathe dust. Keep away from incompatibles such as oxidizing agents.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage

---

Section 8. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering Controls
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
of a Large Spill
handling this product.
Exposure Limits Not available.

---

Section 9. Physical and Chemical Properties
Solid. (Powdered solid.) Not available.
Physical state and O dor
appearance
Not available.
Taste
302.41 g/mole
Molecular Weight
White. Off-white.
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
242°C (467.6°F) -244 C.
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
Not available.
Dispersion Properties
Not available.
Solubility

---

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat, incompatible materials, dust generation.
Incompatibility with various Reactive with oxidizing agents.
substances
Not available.
Corrosivity
Dehydroepiandrosterone, 7-Keto
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

---

Section 11. Toxicological Information
Inhalation. Ingestion.
Routes of Entry
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Other Toxic Effects on
Humans
Not available.
Special Remarks on
Toxicity to Animals
May cause adverse reproductive effects and birth defects (teratogenic).
Special Remarks on
Chronic Effects on Humans May affect genetic material (mutagenic).
May cause cancer
Special Remarks on other Potential Health Effects:
Skin: May cause skin irritation.
Toxic Effects on Humans
Eyes: Dust may cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: May affect the liver, spleen, cardiovascular system(cardiac arrhythmias).
Medical Conditions Aggravated by Exposure: Because it is a precusor of testosterone and estrogen, people with
cancer (such as breast, ovarian, and testicular cancer) should avoid it.; if currently being treated with the following
medications: AZT, Barbiturates, Cisplatin, Steroids, Estrogen.

---

Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation

---

Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control
Waste Disposal
regulations.
Dehydroepiandrosterone, 7-Keto

---

Section 14. Transport Information
DO T Cl assi fi cati on Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DO T (Pi ctograms)

---

Section 15. Other Regulatory Information and Pictograms
California prop. 65: This product contains the following ingredients for which the State of California has found to
Federal and State
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Regulations
Dehydroepiandrosterone, 7-Keto
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause reproductive harm (female) which would require a warning under the statute: Dehydroepiandrosterone, 7-Keto
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause reproductive harm (male) which would require a warning under the statute: Dehydroepiandrosterone, 7-Keto
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
Not available.
Other Regulations
WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
Other Classifications
This product is not classified according Not applicable.
DSCL (EEC)
to the EU regulations.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
Dehydroepiandrosterone, 7-Keto
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or equivalent.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

概述

7-酮基去氢表雄酮（7-keto-dehydroepiandrosterone，简写为7-KetoDHEA），近十余年来经过大量研究证实，其生理活性比DHEA更强，尤其在抗衰老、增强免疫力、改善记忆和脑功能、预防老年痴呆和糖尿病、减少心脏病风险、减肥、增加骨密度及肌肉活力等方面具有显著作用。此外，在人体内不会代谢为性激素（包括男性及女性性激素），无毒副作用，因此比DHEA更为有效且安全。

用途

用作医药中间体

文献信息

• STEROID TETROL SOLID STATE FORMS
  申请人：White Steven K.

  公开号：US20120220560A1

  公开（公告）日：2012-08-30

  The invention relates to solid state forms of androst-5-ene-3β,7β,16α,17β-tetrol, formulations containing or prepared from such solid state forms and use of these materials for modulating unwanted inflammation including acute and chronic non-productive inflammation. The formulations can be used to prevent, treat or slow the progression of conditions related to autoimmunity and metabolic disorders such as arthritis, multiple sclerosis, ulcerative colitis, Type 1 diabetes and Type 2 diabetes.
• [EN] STEROID TETROL SOLID STATE FORMS<br/>[FR] FORMES À L'ÉTAT SOLIDE DE TÉTROL STÉROÏDE
  申请人：HARBOR BIOSCIENCES INC

  公开号：WO2012083161A1

  公开（公告）日：2012-06-21

  The invention relates to solid state forms of androst-5-ene-3β,7β,16α,17β- tetrol, formulations containing or prepared from such solid state forms and use of these materials for modulating unwanted inflammation including acute and chronic non-productive inflammation. The formulations can be used to prevent, treat or slow the progression of conditions related to autoimmunity and metabolic disorders such as arthritis, multiple sclerosis, ulcerative colitis, Type 1 diabetes and Type 2 diabetes.