2-ethyl-1-methyl-4(1H)-quinolone | 139710-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-ethyl-1-methyl-4(1H)-quinolone
• 英文别名: 2-ethyl-1-methyl-4-quinolone；2-Ethyl-1-methylquinolin-4(1H)-one；2-ethyl-1-methylquinolin-4-one
• CAS: 139710-76-2
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: LOBSMKJJIZPJJE-UHFFFAOYSA-N

物化性质

• 沸点：
  284.1±40.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-羟基喹啉 在 氢氧化钾 、 lithium diisopropyl amide 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 2-ethyl-1-methyl-4(1H)-quinolone
  参考文献：
  名称：

  Hetero-ring lithiation of N-methyl-4-quinolone and N-methylquinoline-4-thione

  摘要：

  Lithiation of 1-methyl-4-quinolone and 1-methylquinoline-4-thione with lithium diisopropylamide (LDA) at -78-degrees-C takes place at C-2. The resulting lithio-species react with a variety of electrophiles to give 2-substituted-4-quinolones and -quinolines-4-thiones respectively. 1-Methylquinoline-4-thione is easily converted into 1-methyl-4-quinolone in protic solution.

  DOI：

  10.1039/p19920000351

文献信息

• [EN] USE OF 4-HYDRAZONO-1,4-DIHYDRO-PYRIDINE AND/OR 4-HYDRAZINO-PYRIDINE DERIVATIVES FOR TREATMENT OF HYPERTENSION AND CONGESTIVE HEART FAILURE<br/>[FR] UTILISATION DE DERIVES DE 4-HYDRAZONO-1,4-DIHYDRO-PYRIDINE ET/OU 4-HYDRAZINO-PYRIDINE DANS LE TRAITEMENT DE L'HYPERTENSION ET DE L'INSUFFISANCE CARDIAQUE CONGESTIVE
  申请人：THE UPJOHN COMPANY

  公开号：WO1994007492A1

  公开（公告）日：1994-04-14

  (EN) The present invention provides the use of certain known 4-hydrazono-1,4-dihydro-pyridine and 4-hydrazino pyridine compounds for the treatment of hypertension and congestive heart failure.(FR) La présente invention concerne l'utilisation de certains composés connus de 4-hydrazono-1,4-dihydropyridine et 4-hydrazino pyridine dans le traitement de l'hypertension et de l'insuffisance cardiaque congestive.
• Hetero-ring lithiation of N-methyl-4-quinolone and N-methylquinoline-4-thione
  作者：Mercedes Alvarez、Marisa Salas、Lluis Rigat、Ana de Veciana、John A. Joule

  DOI：10.1039/p19920000351

  日期：——

  Lithiation of 1-methyl-4-quinolone and 1-methylquinoline-4-thione with lithium diisopropylamide (LDA) at -78-degrees-C takes place at C-2. The resulting lithio-species react with a variety of electrophiles to give 2-substituted-4-quinolones and -quinolines-4-thiones respectively. 1-Methylquinoline-4-thione is easily converted into 1-methyl-4-quinolone in protic solution.