5-methyl-6-(methyloxy)-4-pyrimidinamine | 1097180-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-methyl-6-(methyloxy)-4-pyrimidinamine
• 英文别名: 6-Methoxy-5-methylpyrimidin-4-amine
• CAS: 1097180-28-3
• 化学式: C₆H₉N₃O
• 分子量: 139.157
• InChiKey: BWAPPRJGFZWVBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-methyl-6-(methyloxy)-4-pyrimidinamine 在 氢溴酸 、 potassium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (S)-6-amino-3-((3-(2-(4-chlorophenyl)-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)methyl)-5-methylpyrimidin-4(3H)-one
  参考文献：
  名称：

  [EN] PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS
  [FR] COMPOSÉS DE PYRIDONE EN TANT QU'INHIBITEURS DE TRPA1

  摘要：

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same arid method of using the same for treatment of medical conditions, including pain, a skin disorder, a respiratory disease, a fibrotic disease, an inner ear disorder, fever or another disorder of thermoregulation, are also described.

  公开号：

  WO2023215775A1
• 作为产物：
  描述：

  6-氯-5-甲基嘧啶-4-胺 、 sodium methylate 在 甲醇 作用下， 生成 5-methyl-6-(methyloxy)-4-pyrimidinamine
  参考文献：
  名称：

  [EN] PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS
  [FR] COMPOSÉS DE PYRIDONE EN TANT QU'INHIBITEURS DE TRPA1

  摘要：

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same arid method of using the same for treatment of medical conditions, including pain, a skin disorder, a respiratory disease, a fibrotic disease, an inner ear disorder, fever or another disorder of thermoregulation, are also described.

  公开号：

  WO2023215775A1

文献信息

• [EN] IMIDAZO [1, 2-C] PYRIMIDIN-2-YLMETHYLPIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] IMIDAZO [1, 2-C] PYRIMIDIN-2-YLMÉTHYLPIPÉRIDINES COMME ANTAGONISTES VIS-À-VIS DES RÉCEPTEURS DE L'OREXINE
  申请人：GLAXO GROUP LTD

  公开号：WO2009003997A1

  公开（公告）日：2009-01-08

  This invention relates to imidazo[1,2-c]pyrimidin-2-ylmethyl substituted piperidine derivatives and their use as pharmaceuticals.

  这项发明涉及imidazo[1,2-c]嘧啶-2-基甲基取代的哌啶衍生物及其作为药物的应用。
• IMIDAZO [1, 2-C] PYRIMIDIN-2-YLMETHYLPIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Alvaro Giuseppe

  公开号：US20100210667A1

  公开（公告）日：2010-08-19

  Disclosed are imidazo[1,2-c]pyrimidin-2-ylmethyl substituted piperidine derivatives having the formula: where Ar is and where R 1 , R 2 , R 3 , n, p and q are as defined herein, and their use as pharmaceuticals.

  本发明涉及一种具有以下公式的咪唑[1,2-c]嘧啶-2-基甲基取代哌啶衍生物：其中Ar为，R1、R2、R3、n、p和q的定义如本文所述，并且它们作为药物的用途。
• CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION
  申请人：Ren Pingda

  公开号：US20120059000A1

  公开（公告）日：2012-03-08

  Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

  本文描述了调节激酶活性的化合物，包括PI3激酶活性的化合物，以及与激酶活性相关的疾病和病状的化合物、药物组合物和治疗方法。
• IMIDAZO [1, 2-C]PYRIMIDIN-2-YLMETHYLPIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Glaxo Group Limited

  公开号：EP2176265A1

  公开（公告）日：2010-04-21
• US9181221B2
  申请人：——

  公开号：US9181221B2

  公开（公告）日：2015-11-10