6-(Hydroxymethyl)-3-(methylamino)oxane-2,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(Hydroxymethyl)-3-(methylamino)oxane-2,4,5-triol
• 化学式: C₇H₁₅NO₅
• 分子量: 193.2
• InChiKey: OBSLWIKITOYASJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  102
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME
  申请人：AUGER Florian

  公开号：US20110053908A1

  公开（公告）日：2011-03-03

  This disclosure relates to compounds of formula (I): wherein R, R1, R2, R3, R4 and Y are as defined in the disclosure, or an acid addition salt thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

  本公开涉及式(I)化合物：其中R、R1、R2、R3、R4和Y如公开中所定义，或其酸加成盐，以及制备这些化合物的方法及其治疗用途。
• PHENALENE-1-ONE DERIVATIVES, METHOD FOR PRODUCING SAME AND USE THEREOF
  申请人：Bäumler Wolfgang

  公开号：US20140039184A1

  公开（公告）日：2014-02-06

  The present disclosure relates to a compound of formula (1): where R1 through R8, which can be identical or different from each other, each are selected from of the group comprising hydrogen and the radical —(CH 2 ) k —X, where k is a whole number from 1 to 20 and where X is an organic radical comprising a) at least one neutral, protonizable nitrogen atom and/or b) at least one positively charged nitrogen atom, under the provision that at least 1 radical R1 through R8 is not hydrogen. The invention further relates to the production and use of said compound.

  本公开涉及一种化合物，其化学式为(1)：其中R1至R8，可以相同也可以不同，每个都选自包括氢和基团—(CH2)k—X的群体，其中k是1到20的整数，X是一个有机基团，包括a)至少一个中性、可质子化的氮原子和/或b)至少一个带正电荷的氮原子，前提是至少有一个基团R1至R8不是氢。本发明还涉及所述化合物的生产和使用。
• Contrast Agents Endowed with High Relaxivity for Use in Magnetic Resonance Imaging (Mri) Which Contain a Chelating Moiety with Polyhydroxylated Substituents
  申请人：Aime Silvio

  公开号：US20070258905A1

  公开（公告）日：2007-11-08

  The present invention relates to a new class of paramagnetic ion-based contrast agents of molecular weight lower than 3.5 kDa that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents and that are further characterized by a higher relaxivity.

  本发明涉及一种新的顺磁离子基对比剂，其分子量低于3.5 kDa，显示类似于常用的T1通用非血管内对比剂的药代动力学特征，并且具有更高的弛豫度。
• Contrast agents endowed with high relaxivity
  申请人：Aime Silvio

  公开号：US20110256067A1

  公开（公告）日：2011-10-20

  The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.

  本发明涉及一种新型的基于顺磁离子的对比剂类别，其化学式为(I)，其中螯合骨架部分通过一个或多个多羟基链的存在高度功能化，表现出与常用的T1通用非血管外用对比剂(NSA)相似的药代动力学特征，但具有更高的弛豫度。
• Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
  申请人：Novartis AG

  公开号：US10081697B2

  公开（公告）日：2018-09-25

  The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

  本发明提供了一种亲水聚二有机硅氧烷乙烯基交联剂，它包括(1)聚二有机硅氧烷聚合物链，该链由二甲基硅氧烷单元和亲水硅氧烷单元组成，每个二甲基硅氧烷单元具有一个甲基取代基和一个具有二至六个羟基的单价C4-C40有机基取代基，其中亲水硅氧烷单元与二甲基硅氧烷单元的摩尔比为约0.035至约0.15，以及(2)两个末端(甲基)丙烯酰基。亲水性聚二有机硅氧烷乙烯基交联剂的平均分子量为约 3000 道尔顿至约 80000 道尔顿。本发明还涉及一种硅酮水凝胶隐形眼镜，它包括由本发明的亲水聚二有机硅氧烷乙烯基交联剂衍生的重复单元。