1-Methyl-2,3,4,5-tetrahydroazepino[2,3-b]quinolin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Methyl-2,3,4,5-tetrahydroazepino[2,3-b]quinolin-6-amine
• 化学式: C₁₄H₁₇N₃
• 分子量: 227.3
• InChiKey: OQXXXDZZPGCHKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Small molecule toll-like receptor (TLR) antagonists
  申请人：Lipford B. Grayson

  公开号：US20050119273A1

  公开（公告）日：2005-06-02

  The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.

  本发明提供了用于调节通过Toll样受体信号传导的方法和组合物。该方法涉及使用含有至少两个环的核心结构的小分子与表达TLR的细胞接触。其中某些化合物是4-主氨基喹啉。许多化合物和方法特别适用于抑制涉及至少一个TLR9、TLR8、TLR7和TLR3的免疫刺激。该方法可用于治疗自身免疫、炎症、过敏、哮喘、移植排斥、移植物抗宿主病、感染、败血症、癌症和免疫缺陷。
• Quinoline compound
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0430485A2

  公开（公告）日：1991-06-05

  There is disclosed a quinoline compound represented by the following formula (I): wherein R¹ and R² each represent a hydrogen atom, a halogen atom, a lower alkyl group, a trifluoromethyl group, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, a nitro group, an amino group or a lower alkanoylamino group; R³ represents a hydrogen atom, an alkyl group having 1 to 15 carbon atoms, a cycloalkyl group, an aralkyl group having 7 to 15 carbon atoms which may be substituted by a halogen atom, a lower alkyl group or a lower alkoxy group, an alkanoyl group having 2 to 15 carbon atoms, or a benzoyl group which may be substituted by a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, a hydroxy group or an amino group; and n represents an integer of 2 to 5, and an acid addition salt thereof.

  本发明公开了由下式（I）代表的喹啉化合物： 其中 R¹ 和 R² 各自代表氢原子、卤素原子、低级烷基、三氟甲基、羟基、低级烷氧基、低级烷酰氧基、硝基、氨基或低级烷酰氨基；R³ 代表氢原子、具有 1 至 15 个碳原子的烷基、环烷基、具有 7 至 15 个碳原子且可被卤素原子、低级烷基或低级烷氧基取代的芳烷基、具有 2 至 15 个碳原子的烷酰基或可被卤素原子、低级烷基、低级烷氧基、硝基、羟基或氨基取代的苯甲酰基；以及 n 代表 2 至 5 的整数、 及其酸加成盐。
• TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS
  申请人：Pharmacyclics LLC

  公开号：EP3220912A1

  公开（公告）日：2017-09-27
• RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES
  申请人：CureVac AG

  公开号：EP4013880A1

  公开（公告）日：2022-06-22
• US7410975B2
  申请人：——

  公开号：US7410975B2

  公开（公告）日：2008-08-12